Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease

作者全名："Wang, Linshuang; Xu, Xiaoyu; Wang, Zikang; Chen, Qian; Wei, Xiaodie; Xue, Jingfan; Zhang, Zhanjun; Wang, Miao; Li, Yanping; Zhang, Junying; Wei, Dongfeng"

作者地址："[Wang, Linshuang; Zhang, Junying; Wei, Dongfeng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China; [Xu, Xiaoyu; Wang, Zikang; Chen, Qian; Wang, Miao; Li, Yanping] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China; [Xu, Xiaoyu; Li, Yanping] Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China; [Wei, Xiaodie] Xian Med Univ, Xian 710000, Peoples R China; [Xue, Jingfan] Huaiyin Normal Univ, Huaian 223001, Peoples R China; [Zhang, Zhanjun] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China; [Zhang, Zhanjun] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China; [Zhang, Zhanjun] Beijing Normal Univ, BABRI Ctr, Beijing 100875, Peoples R China"

通信作者："Zhang, JY; Wei, DF (通讯作者)，China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.; Li, YP (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.; Li, YP (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China."

来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000820668200005

JCR分区：Q3

影响因子：2.65

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background. Traditional Chinese herbal medicine draws more attention to explore an effective therapeutic strategy for Alzheimer's disease (AD). Shenqi Yizhi granule (SQYG), a Chinese herbal recipe, has been applied to ameliorate cognitive impairment in mild-to-moderate AD patients. However, the overall molecular mechanism of SQYG in treating AD has not been clarified. Objective. This study aimed to investigate the molecular mechanism of SQYG on AD using an integration strategy of network pharmacology and molecular docking. Methods. The active compounds of SQYG and common targets between SQYG and AD were screened from databases. The herb-compound network, compound-target network, and protein-protein interaction network were constructed. The enrichment analysis of common targets and molecular docking were performed. Results. 816 compounds and 307 common targets between SQYG and AD were screened. KEGG analysis revealed that common targets were mainly enriched in lipid metabolism, metal ion metabolism, IL-17 signaling pathway, GABA receptor signaling, and neuroactive ligand-receptor interaction. Molecular docking analysis showed high binding affinity between ginsenoside Rg1 and A beta(1-42), tanshinone IIA and BACE1, baicalin, and AchE. Conclusions. The therapeutic mechanisms of SQYG on AD were associated with regulating lipid metabolism, metal ion metabolism, IL-17 signaling pathway, and GABA receptor signaling. Ginsenoside Rg1, tanshinone IIA, baicalin, astragaloside IV, and folic acid may play an important role in AD treatment."

基金机构："National Natural Science Foundation of China [82174210, 81603488]; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning [CNLZD1504]; Scientific and technological innovation project of China Academy of Chinese Medical Sciences [CI2021B003]; State Key Program of National Natural Science Foundation of China [81430100]; National Key Research and Development Project of China [2018YFC1315203]; Youth Program of National Natural Science Foundation of China [81803965]; Fundamental Research Funds for the Central Public Welfare Research Institutes [ZZ13-YQ-073]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (grant number: 82174210 and 81603488), the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning (grant number: CNLZD1504), the Scientific and technological innovation project of China Academy of Chinese Medical Sciences (grant number: CI2021B003), the State Key Program of National Natural Science Foundation of China (grant number: 81430100), National Key Research and Development Project of China (grant number: 2018YFC1315203), the Youth Program of National Natural Science Foundation of China (grant number: 81803965), and the Fundamental Research Funds for the Central Public Welfare Research Institutes (grant number: ZZ13-YQ-073)."