Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse

作者全名："Wang, Peng-Fei; Xie, Ke; Cao, Yun-Xing; Zhang, An"

作者地址："[Wang, Peng-Fei; Xie, Ke; Cao, Yun-Xing; Zhang, An] Chongqing Med Univ, Dept Crit Care Med, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Zhang, A (通讯作者)，Chongqing Med Univ, Dept Crit Care Med, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：MEDIATORS OF INFLAMMATION

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000820888600001

JCR分区：Q3

影响因子：4.6

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："The liver is vulnerable to sepsis, and sepsis-induced liver injury is closely associated with poor survival of sepsis patients. Studies have found that the overproduction of reactive oxygen species (ROS) is the major cause of oxidative stress, which is the main pathogenic factor for the progression of septic liver injury. The mitochondria are a major source of ROS. Mito-TEMPO is a mitochondria-specific superoxide scavenger. The aim of this study was to investigate the effect of Mito-TEMPO on lipopolysaccharide- (LPS-) induced sepsis mice. We found that Mito-TEMPO pretreatment inhibited inflammation, attenuated LPS-induced liver injury, and enhanced the antioxidative capability in septic mice, as evidenced by the decreased MDA content and the increased SOD activity. In addition, Mito-TEMPO restored mitochondrial size and improved mitochondrial function. Finally, we found that the levels of pyroptosis-related proteins in the liver of LPS-treated mice were lower after pretreatment with Mito-TEMPO. The mechanisms could be related to Mito-TEMPO enhanced antioxidative capability and improved mitochondrial function, which reflects the ability to neutralize ROS."

基金机构：Emergency Research Project of COVID-19 of the Chongqing Health Commission [2020NCPZX04]; Chongqing Special Research Project for Novel Coronavirus Pneumonia Prevention and Control [cstc2020jscx-fyzxX0012]

基金资助正文：AcknowledgmentsThis work was supported by the Emergency Research Project of COVID-19 of the Chongqing Health Commission (#2020NCPZX04 to AZ) and the Chongqing Special Research Project for Novel Coronavirus Pneumonia Prevention and Control (#cstc2020jscx-fyzxX0012 to AZ). We are grateful to professor Fang Xu for providing laboratory support.