"Clinical implementation of ketogenic diet in children with drug-resistant epilepsy: Advantages, disadvantages, and difficulties"

作者全名："Tong, Xin; Deng, Yao; Liu, Ling; Tang, Xiang; Yu, Tao; Gan, Jing; Cai, Qianyun; Luo, Rong; Xiao, Nong"

作者地址："[Tong, Xin; Deng, Yao; Yu, Tao; Gan, Jing; Cai, Qianyun; Luo, Rong] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China; [Tong, Xin; Deng, Yao; Yu, Tao; Gan, Jing; Cai, Qianyun; Luo, Rong] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China; [Liu, Ling; Tang, Xiang; Xiao, Nong] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Rehabil Med,Minist Educ,Key Lab Child Dev &, Chongqing, Peoples R China"

通信作者："Xiao, N (通讯作者)，Sichuan Univ, West China Univ Hosp 2, 20,Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.; Luo, R (通讯作者)，Chongqing Med Univ, Childrens Hosp, 136,Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000821623500009

JCR分区：Q2

影响因子：3

年份：2022

卷号：99

期号：　

开始页：75

结束页：81

文献类型：Article

关键词：Children with epilepsy; Clinical practice; Disadvantages; Discontinuation; Ketogenic diet; Southwest China

摘要："Purpose: Ketogenic diet (KD) is a well-established nonpharmacologic treatment for drug-resistant epilepsy. However, although KD has a long history of clinical use, there are still many difficulties with its real-world practice. This study retrospectively described the situation of KD practice in two children???s hospitals in South -west China. Methods: We reviewed and analyzed clinical data collected at the baseline, and during follow ups at 1, 3, 6, 12, 18, and 24 months. The patient retention, the efficacy, side effects of KD, and the reasons for discontinuation were focused. Results: There was increasing availability of KD for children with epilepsy in Southwest China and its effec-tiveness in controlling seizures was reconfirmed. Nonetheless, less than half of the patients adhered to KD for one year and about 1/5 of the patients for two years. Unsatisfactory seizure control was the most common reason for discontinuation, followed by patient/caregiver preference, acute infection, and loss to follow up. Adverse effects were mostly tolerable and not the main reason for discontinuation. Meanwhile, KD showed negative impacts on linear growth, and our cohort seemed to have more infections and deaths. Conclusions: Despite increasing availability and good efficacy, long-term adherence to KD was difficult. Compliance issues appeared to be prominent. Enhancing food taste and patient support can help to improve the retention rate."

基金机构：National Natural Science Foundation of China [82101523]; Regional Innovation Cooperation Project of Sichuan Provincial Science and Technology Department [2020YFQ0021]; Horizontal Scientific Research Project of Sichuan University [20H0072]

基金资助正文："This work was supported by the National Natural Science Foundation of China under Grants No. 82101523, the Regional Innovation Cooperation Project of Sichuan Provincial Science and Technology Department under Grant No. 2020YFQ0021, and the Horizontal Scientific Research Project of Sichuan University under Grant No. 20H0072."