Sex differences on outcomes following left atrial appendage occlusion in atrial fibrillation: A systematic review and meta-analysis

作者全名："Zhu, Yuansong; Sasmita, Bryan Richard; Xue, Yuzhou; Jiang, Yi; Huang, Bi; Luo, Suxin"

作者地址："[Zhu, Yuansong; Sasmita, Bryan Richard; Xue, Yuzhou; Jiang, Yi; Huang, Bi; Luo, Suxin] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Huang, B; Luo, SX (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000821785700001

JCR分区：Q2

影响因子：2.3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：atrial fibrillation; gender; left atrial appendage occlusion; meta-analysis; sex

摘要："There is a lack of sufficient data on sex-related differences in outcomes of nonvalvular atrial fibrillation (AF) patients following left atrial appendage occlusion (LAAO). We conducted a meta-analysis to investigate the procedural complications and long-term outcomes after LAAO in women versus men. We screened Medline, EMBASE, Cochrane Center Register of Controlled Trials, and Clinical . The inclusion criteria were studies targeting the sex-related differences in outcomes in nonvalvular AF patients treated by LAAO. Procedural endpoints of interest included success rate, pericardial complications, major bleeding, and vascular complications during hospitalization. Long-term outcomes included all-cause mortality and ischemic stroke during follow-up. Studies that merely considered sex in the subgroup analysis were not included. Six observational studies with a total of 64,035 patients were identified. The procedural success rates did not differ between sexes (odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.89-1.09, p = 0.77), while women experienced more pericardial complications (OR: 1.78, 95% CI: 1.58-2.01, p < 0.00001), major bleedings (OR: 2.04, 95% CI: 1.75-2.39, p < 0.00001), and vascular complications (OR: 1.75, 95% CI: 1.41-2.17, p < 0.00001) than men. The sensitivity analysis performed by removing the largest study showed good stability. The long-term mortality and stroke rates did not differ between women and men in either the 1-year subgroup or the 2-year subgroup. In conclusion, despite comparable procedural success rates, women have a significantly higher incidence of pericardial complications, major bleeding, and vascular complications following LAAO. The long-term mortality and stroke rates do not differ between the sexes."

基金机构：　

基金资助正文：