Learning Curve of USgHIFU Ablation for Uterine Fibroids A Multi-Center Prospective Study

作者全名："Liu, Dang; Zhang, Xinyue; Gong, Xue; Yang, Chao; Zhang, Rong; Chen, Wenzhi; Chen, Jinyun"

作者地址："[Liu, Dang; Gong, Xue; Yang, Chao; Zhang, Rong; Chen, Wenzhi; Chen, Jinyun] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Zhang, Xinyue] Mianyang Cent Hosp, Dept Ultrasound Med, Mianyang, Sichuan, Peoples R China; [Chen, Jinyun] Chongqing Med Univ, Affiliated Hosp 1, HIFU Ctr Tumor Therapy, Chongqing, Peoples R China"

通信作者："Chen, JY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China."

来源：JOURNAL OF ULTRASOUND IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000821825900001

JCR分区：Q2

影响因子：2.3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：high-intensity focused ultrasound; learning curve; operation; training; uterine fibroids

摘要："Objectives To verify the stability of high-intensity focused ultrasound (HIFU) technology and the feasibility of training programs with learning curve cumulative summation (LC-CUSUM). Methods A total of 12 physicians and 720 cases were equally assigned to the learning group and the control group, with 6 physicians and 360 cases per group. The learning group was treated by physicians without HIFU experience and the control group was treated by experienced physicians. Nonperfused volume (NPV) ratio was assessed by contrast-enhanced magnetic resonance imaging. Technical failure was defined as NPV ratio of uterine fibroids <70% and/or major complication, while <80% was set as a stricter standard of training qualification. LC-CUSUM was used to analyze the learning curve. Results Physicians with or without HIFU experience in both groups achieved matchable NPV ratios, where a NPV ratio of 92.52% (16.06) was achieved by experienced physicians and 93.82% (16.95) by inexperienced physicians. No major complication was observed. The results of LC-CUSUM analysis showed that, with the standards of the NPV ratio of 70% or 80%, the learning group mastered the technique on the 11th case and the 16th case, respectively, while the control group was stable. Conclusions HIFU technology stayed stable in operation, with good safety and sound effectiveness, and was easy to learn. NPV ratio of 70% was considered as an appropriate indicator of training qualification. HIFU has remarkable prospects in achieving a NPV ratio of >= 80% without safety being compromised."

基金机构：Chongqing Medical University Intelligent Medicine Project [ZHYX2019007]

基金资助正文：The authors thank the training physicians who provided research information in this study. The authors also thank the contribution of clinical staff for the recruitment of patients and the delivery of clinical care. This study was supported by the Chongqing Medical University Intelligent Medicine Project (grant number ZHYX2019007).