Reduced Circulating Soluble Receptor for Advanced Glycation End-products in Chronic Hepatitis B Are Associated with Hepatic Necroinflammation

作者全名："Zhang, Xiuyu; You, Yan; Liu, Qiao; Sun, Xiaoyu; Chen, Weixian; Duan, Liang"

作者地址："[Zhang, Xiuyu; Sun, Xiaoyu; Chen, Weixian; Duan, Liang] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [You, Yan] Chongqing Med Univ, Dept Pathol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Liu, Qiao] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Duan, L (通讯作者)，Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：INFLAMMATION

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000822014900001

JCR分区：Q2

影响因子：5.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：soluble RAGE; HBV; chronic hepatitis B; biomarker

摘要："The diagnosis and disease management of chronic hepatitis B (CHB) remain challenging due to the elusive assessment of disease severity. Recently, soluble receptor for advanced glycation end-products (sRAGE) has been implicated in the inflammatory-immune response initiated by liver injury. Nonetheless, its natural behavior and clinical importance in CHB remain elusive. One hundred and twenty CHB patients and forty healthy controls (HCs) were enrolled, and the serum sRAGE as well as RAGE expression in biopsy specimens from these subjects was analyzed, and correlation of sRAGE with clinical features as well as its potential predictive value for monitoring the CHB was also evaluated. Reduced serum sRAGE levels and decreased tissular RAGE expression were observed in CHB patients. sRAGE and RAGE were inversely correlated with gradually increased grades of hepatic necroinflammation as well as the routine indicator ALT. Furthermore, receiver operating characteristic (ROC) analysis showed that combination of ALT and sRAGE exerted better predictive power (area under the ROC curve (AUC) of 0.86) for hepatic necroinflammation than that of ALT (AUC of 0.82), sRAGE (AUC of 0.81), or sRAGE-to-ALT ratio (sRAGE/ALT) (AUC of 0.85) alone. More importantly, circulating sRAGE alone exerted valuable predictive power for hepatic moderate-to-severe necroinflammation in CHB patients but with normal ALT (AUC of 0.81) or minimally elevated ALT (AUC of 0.85). In conclusion, reduced serum sRAGE levels may imply an increased severity for necroinflammation, and it may serve as a potential alternative biomarker for monitoring hepatic necroinflammation in CHB."

基金机构：National Natural Science Foundation of China [82072364]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0864]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This work was supported by the National Natural Science Foundation of China (82072364), Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0864), and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."