"Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version"

作者全名："Xie, Jiaxi; Zhong, Cailing; Wang, Tingting; He, Dan; Lu, Luyang; Yang, Jie; Yuan, Ziyi; Zhang, Jingqing"

作者地址："[Xie, Jiaxi; Zhong, Cailing; He, Dan; Yang, Jie; Yuan, Ziyi; Zhang, Jingqing] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing, Peoples R China; [Wang, Tingting] Chongqing Med Univ, Expt Teaching & Management Ctr, Biochem & Mol Biol Lab, Chongqing, Peoples R China; [Lu, Luyang] Southwest Minzu Univ, Coll Pharm, Chengdu, Peoples R China"

通信作者："Zhang, JQ (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000822821200001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：cerebral metabolism; natural medicines; pharmacokinetics; pharmacodynamics; delivery systems

摘要："Currently, many people are afflicted by cerebral diseases that cause dysfunction in the brain and perturb normal daily life of people. Cerebral diseases are greatly affected by cerebral metabolism, including the anabolism and catabolism of neurotransmitters, hormones, neurotrophic molecules and other brain-specific chemicals. Natural medicines (NMs) have the advantages of low cost and low toxicity. NMs are potential treatments for cerebral diseases due to their ability to regulate cerebral metabolism. However, most NMs have low bioavailability due to their low solubility/permeability. The study is to summarize the better bioactivity, cerebral metabolism and pharmacokinetics of NMs and its advanced version. This study sums up research articles on the NMs to treat brain diseases. NMs affect cerebral metabolism and the related mechanisms are revealed. Nanotechnologies are applied to deliver NMs. Appropriate delivery systems (exosomes, nanoparticles, liposomes, lipid polymer hybrid nanoparticles, nanoemulsions, protein conjugation and nanosuspensions, etc.) provide better pharmacological and pharmacokinetic characteristics of NMs. The structure-based metabolic reactions and enzyme-modulated catalytic reactions related to advanced versions of NMs alter the pharmacological activities of NMs."

基金机构：National Natural Science Foundation of China [30973645]; Chongqing Association of Science and Technology [2020-11]; Chongqing Education Committee [CYS20212]

基金资助正文："Funding This work was partially supported by grants from National Natural Science Foundation of China (30973645), Chongqing Association of Science and Technology (2020-11), Chongqing Education Committee (CYS20212)."