Causal effect of autoimmune liver diseases on cancer: Meta-analyses of cohort studies and Mendelian randomization study

作者全名："Gu, Dongqing; Zhang, Min; Wang, Yutong; Bai, Ye; Wang, Xin; Deng, Guohong"

作者地址："[Gu, Dongqing; Deng, Guohong] Army Med Univ, Affiliated Hosp 1, Dept Infect Dis, 30 Gaotanyan St, Chongqing 400038, Peoples R China; [Zhang, Min; Bai, Ye] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Wang, Yutong; Wang, Xin] Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China"

通信作者："Deng, GH (通讯作者)，Army Med Univ, Affiliated Hosp 1, Dept Infect Dis, 30 Gaotanyan St, Chongqing 400038, Peoples R China.; Wang, X (通讯作者)，Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China."

来源：LIVER INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000825843700001

JCR分区：Q1

影响因子：6.7

年份：2022

卷号：42

期号：10

开始页：2216

结束页：2226

文献类型：Article

关键词：autoimmune hepatitis; autoimmune liver diseases; cancer; Mendelian randomization; primary biliary cholangitis; primary sclerosing cholangitis

摘要："Background and Aims Prior studies suggested that patients with autoimmune liver diseases (AiLDs) had an increased risk of cancer, whereas the causal effect remained unclear. Methods Meta-analyses concerning the relationship between AiLD and cancer risk were performed to calculate the pooled relative risk (RR) and corresponding 95% confidence intervals (CIs). Then, the associations with a p value of A total of 37 cohort studies covering more than 34 558 patients were included, and we observed an increased risk of overall cancers (pooled RR = 3.64, 95% CI: 2.64-5.03, p < .001) and cancer-related death (pooled RR = 2.48, 95% CI: 1.73-3.53, p < .001) for patients with AiLD. Besides, overall and several site-specific cancers risk were found in patients with primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) (p < .05). However, associations between genetically predisposed AIH, PBC, and PSC and the risk of specific cancers did not reach a significant level, except for PBC and gastric cancer (OR = 0.96, 95% CI: 0.93-0.99; p = .02). Conclusions In addition to hepatobiliary cancer, results from the meta-analyses suggest that patients with AiLD might have an increased risk of several extrahepatobiliary cancers. However, the causal role of AiLD in cancer development needs to be further investigated."

基金机构："Chongqing Natural Science Foundation Program [cstc2020jcyj--msxmX0021, cstc2019jcyj--msxmX0466]; Chongqing Postdoctoral Science Special Foundation [XmT2018068]; National Natural Science Foundation of China [81903393, 81903398]"

基金资助正文："Chongqing Natural Science Foundation Program, Grant/Award Number: cstc2020jcyj--msxmX0021 and cstc2019jcyj--msxmX0466; Chongqing Postdoctoral Science Special Foundation, Grant/Award Number: XmT2018068; National Natural Science Foundation of China, Grant/Award Number: 81903393 and 81903398"