The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

作者全名："He, Zhimin; Chen, Rongsheng; Hu, Shangying; Zhang, Yajiao; Liu, Yang; Li, Chengwei; Lv, Fajin; Xiao, Zhibo"

作者地址："[He, Zhimin; Liu, Yang; Li, Chengwei; Lv, Fajin] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [He, Zhimin; Liu, Yang; Li, Chengwei; Lv, Fajin] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Chen, Rongsheng; Liu, Yang; Lv, Fajin; Xiao, Zhibo] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Hu, Shangying] Chongqing Med Univ, Dept Gynecol & Obstet, Univ Town Hosp, Chongqing 401331, Peoples R China; [Zhang, Yajiao] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Lv, Fajin] Chongqing Med Univ, Inst Med Data, Chongqing 400016, Peoples R China"

通信作者："Lv, FJ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.; Lv, FJ (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China.; Lv, FJ; Xiao, ZB (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Lv, FJ (通讯作者)，Chongqing Med Univ, Inst Med Data, Chongqing 400016, Peoples R China."

来源：BMC CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000826041600008

JCR分区：Q2

影响因子：3.8

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Cervical cancer; Adenocarcinoma; Squamous cell carcinoma; Human papilloma virus; Tumour marker

摘要："Background To investigate the differences in HPV genotypes and clinical indicators between cervical squamous cell carcinoma and adenocarcinoma and to identify independent predictors for differentiating cervical squamous cell carcinoma and adenocarcinoma. Methods A total of 319 patients with cervical cancer, including 238 patients with squamous cell carcinoma and 81 patients with adenocarcinoma, were retrospectively analysed. The clinical characteristics and laboratory indicators, including HPV genotypes, SCCAg, CA125, CA19-9, CYFRA 21-1 and parity, were analysed by univariate and multivariate analyses, and a classification model for cervical squamous cell carcinoma and adenocarcinoma was established. The model was validated in 96 patients with cervical cancer. Results There were significant differences in SCCAg, CA125, CA19-9, CYFRA 21-1, HPV genotypes and clinical symptoms between cervical squamous cell carcinoma and adenocarcinoma (P < 0.05). Logistic regression analysis showed that SCCAg and HPV genotypes (high risk) were independent predictors for differentiating cervical squamous cell carcinoma from adenocarcinoma. The AUC value of the established classification model was 0.854 (95% CI: 0.804-0.904). The accuracy, sensitivity and specificity of the model were 0.846, 0.691 and 0.899, respectively. The classification accuracy was 0.823 when the model was verified. Conclusion The histological type of cervical cancer patients with persistent infection of high-risk HPV subtypes and low serum SCCAg levels was more prone to being adenocarcinoma. When the above independent predictors occur, the occurrence and development of cervical adenocarcinoma should be anticipated, and early active intervention treatment should be used to improve the prognosis and survival of patients."

基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission) [2021MSXM102]; Chongqing medical scientific research project ( Science and Technology Bureau) [2021MSXM102]

基金资助正文："This study was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [grant number 2021MSXM102] and Chongqing Science and Technology Commission (#cstc2018jscx-mszdX0042). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript."