Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering

作者全名："Ao, Yunong; Zhang, En; Liu, Yangxi; Yang, Liu; Li, Jun; Wang, Fuyou"

作者地址："[Ao, Yunong; Yang, Liu; Li, Jun; Wang, Fuyou] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China; [Zhang, En; Li, Jun] Chongqing Inst Food & Drug Control, Chongqing, Peoples R China; [Liu, Yangxi] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China"

通信作者："Li, J; Wang, FY (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China.; Li, J (通讯作者)，Chongqing Inst Food & Drug Control, Chongqing, Peoples R China."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000826713700001

JCR分区：Q1

影响因子：5.7

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：nanoparticles; composite hydrogels; tissue engineering; cartilage; repairing

摘要："Cartilage dysfunctions caused by congenital disease, trauma and osteoarthritis are still a serious threat to joint activity and quality of life, potentially leading to disability. The relatively well-established tissue engineering technology based on hydrogel is a promising strategy for cartilage defect repairing. However, several unmet challenges remain to be resolved before its wide application and clinical translation, such as weak mechanical property and compromised bioactivity. The development of nanomedicine has brought a new dawn to cartilage tissue engineering, and composite hydrogel containing nanoparticles can substantially mimic natural cartilage components with good histocompatibility, demonstrating unique biological effects. In this review, we summarize the different advanced nanoparticle hydrogels currently adopted in cartilage tissue engineering. In addition, we also discuss the various application scenarios including injection and fabrication strategies of nanocomposite hydrogel in the field of cartilage repair. Finally, the future application prospects and challenges of nanocomposite hydrogel are also highlighted."

基金机构：National Natural Science Foundation of China [82172429]; Department of Science and Technology of Chongqing Province [cstc2021jxjl130014]

基金资助正文："Funding The authors acknowledge the funding provided by National Natural Science Foundation of China (No. 82172429), Department of Science and Technology of Chongqing Province (No. cstc2021jxjl130014)."