Engineering manganese ferrite shell on iron oxide nanoparticles for enhanced T-1 magnetic resonance imaging

作者全名："Li, Muyao; Bao, Jianfeng; Zeng, Jie; Huo, Linlin; Shan, Xinxin; Cheng, Xintong; Qiu, Dachuan; Miao, Wenjun; Zhu, Xianglong; Huang, Guoming; Ni, Kaiyuan; Zhao, Zhenghuan"

作者地址："[Li, Muyao; Zeng, Jie; Huo, Linlin; Qiu, Dachuan; Miao, Wenjun; Zhao, Zhenghuan] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Bao, Jianfeng] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Funct Magnet Resonance & Mol Imaging Key Lab Henan, Zhengzhou 450001, Peoples R China; [Shan, Xinxin; Cheng, Xintong; Huang, Guoming] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China; [Zhu, Xianglong] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China; [Ni, Kaiyuan] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA"

通信作者："Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.; Ni, KY (通讯作者)，MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA."

来源：JOURNAL OF COLLOID AND INTERFACE SCIENCE

ESI学科分类：CHEMISTRY

WOS号：WOS:000826956900001

JCR分区：Q1

影响因子：9.9

年份：2022

卷号：626

期号：　

开始页：364

结束页：373

文献类型：Article

关键词：Surface optimization; T-1 contrast agent; Iron oxide nanoparticles; Manganese ions

摘要："Doping Mn (II) ions into iron oxide (IO) as manganese ferrite (MnIO) has been proved to be an effective strategy to improve T-1 relaxivity of IO nanoparticle in recent years; however, the high T-2 relaxivity of MnIO nanoparticle hampers its T-1 contrast efficiency and remains a hurdle when developing contrast agent for early and accurate diagnosis. Herein, we engineered the interfacial structure of IO nanoparticle coated with manganese ferrite shell (IO@MnIO) with tunable thicknesses. The Mn-doped shell signifi-cantly improve the T-1 contrast of IO nanoparticle, especially with the thickness of-0.8 nm. Compared to pristine IO nanoparticle, IO@MnIO nanoparticle with thickness of-0.8 nm exhibits nearly 2 times higher T-1 relaxivity of 9.1 mM(-1)s(-1) at 3 T magnetic field. Moreover, exclusive engineering the interfacial structure significantly lower the T-2 enhancing effect caused by doped Mn (II) ions, which further limits the impairing of increased T-2 relaxivity to T-1 contrast imaging. IO@MnIO nanoparticles with different shell thicknesses reveal comparable T-1 relaxation rates but obvious lower T-2 relaxivities and r(2)/r(1) ratios to MnIO nanoparticles with similar sizes. The desirable T-1 contrast endows IO@MnIO nanoparticle to pro-vide sufficient signal difference between normal and tumor tissue in vivo. This work provides a detailed instance of interfacial engineering to improve IO-based T-1 contrast and a new guidance for designing effective high-performance T-1 contrast agent for early cancer diagnosis. (C) 2022 Elsevier Inc. All rights reserved."

基金机构："National Natural Science Foundation of China [81601607, 81971609, 82001869]; Creative Research Group of CQ University [CXQT21017]; Chongqing High-level Personnel of Special Support Program [CQYC201905077]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81601607, 81971609, and 82001869) , Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent CQYC201905077) , and Creative Research Group of CQ University (CXQT21017) ."