Signal-on and selective detection of anti-tumor adjunctive drug zoledronic acid using fluorescent sulfur quantum dots

作者全名："Tan, Juan; Deng, Ping; Wang, Li; Bi, Xiaoya; Zhou, Yiyao; Wang, Yi; Zhang, Pu"

作者地址："[Tan, Juan; Bi, Xiaoya; Zhou, Yiyao; Wang, Yi] Chongqing Normal Univ, Coll Chem,Minist Educ, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat, Chongqing 401331, Peoples R China; [Deng, Ping; Zhang, Pu] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China; [Wang, Li] Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Wang, Y (通讯作者)，Chongqing Normal Univ, Coll Chem,Minist Educ, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat, Chongqing 401331, Peoples R China.; Zhang, P (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：DYES AND PIGMENTS

ESI学科分类：CHEMISTRY

WOS号：WOS:000827452600001

JCR分区：Q1

影响因子：4.5

年份：2022

卷号：205

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Photoluminescence; Sulfur; Ferricions; Bisphosphonate; Fluorescence quenching

摘要："As a representative of the third generation of bisphosphonate drugs, zoledronic acid (ZA) is clinically used to treat osteolytic bone metastases from malignant tumors and osteoporosis. Herein, a novel signal-on strategy for highly selective detection of ZA is proposed, employing Fe3+-mediated fluorescent sulfur quantum dots (SQDs) as a probe. Specifically, Fe3+ can induce the aggregation of SQDs in aqueous solution and strongly quench their fluorescence, however, which recovers again in the presence of ZA owing to its emulative complexation with Fe3+. The complex ratio and binding mode between ZA and Fe3+ are also theoretically simulated. This method exhibits the merits of rapidness, high selectivity, reliability, and with no need of derivatization for ZA detection, with a detectable range of 5-200 mu M and a detection limit of 1.7 mu M. It has also been successfully applied to determine ZA in real samples including human serum, urine, and drugs."

基金机构："National Natural Science Foundation of China [21775014, 81972020]; Chongqing Innovation Research Group Project [CXQT21015]; Chongqing Talent Program [202010637002]; National College Students Innovation and Entrepreneurship Training Program of China"

基金资助正文：Acknowledgements This work was supported by the National Natural Science Foundation of China (no. 21775014 and 81972020) and Chongqing Innovation Research Group Project (no. CXQT21015) . P.Z. was also sponsored by the Chongqing Talent Program. X.B. and Y.Z. were also supported by the National College Students Innovation and Entrepreneurship Training Program of China (no. 202010637002) .