Efficacy of Resveratrol in Experimental Subarachnoid Hemorrhage Animal Models: A Stratified Meta-Analysis

作者全名："Tan, Jiahe; Song, Rui; Luo, Siyue; Fu, Wenqiao; Ma, Yinrui; Zheng, Lian; He, Zhaohui"

作者地址："[Tan, Jiahe; Fu, Wenqiao; Ma, Yinrui; He, Zhaohui] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [Song, Rui] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis,Affiliated Hosp 2, Key Lab Mol Biol Infect Dis,Minist Educ, Chongqing, Peoples R China; [Luo, Siyue] Chongqing Med Univ, Clin Med, Clin Coll 2, Chongqing, Peoples R China; [Zheng, Lian] Fifth Peoples Hosp Chongqing Municipal, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："He, ZH (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China.; Zheng, L (通讯作者)，Fifth Peoples Hosp Chongqing Municipal, Dept Neurosurg, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000827661000001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：resveratrol; subarachnoid hemorrhage; animal models; neuroprotection; meta-analysis

摘要："Background: Subarachnoid hemorrhage (SAH) is a serious neurosurgical emergency with extremely high morbidity and mortality rates. Resveratrol (RES), a natural polyphenolic phytoalexin, is broadly presented in a wide variety of plants. Previous research had reasonably revealed its neuroprotective effects on experimental SAH animal models to some extent. But the results were more controversial. Therefore, we conducted a meta-analysis to evaluate the evidence on the effectiveness of RES in improving outcomes in SAH animal models. Methods: A systematic literature review was conducted in PubMed, EMBASE, and Web of Science databases to incorporate experimental control studies on the efficacy of RES on SAH models into our research. The standardized mean difference (SMD) was used to compare the brain water content (BWC) and neurological score (NS) between the treatment and control groups. Results: Overall, 16 articles published from 2014 to 2022 met the inclusion criteria. The meta-analysis of BWC showed a significant difference in favor of RES treatment (SMD: -1.026; 95% CI: -1.380, -0.672; p = 0.000) with significant heterogeneity (Q = 84.97; I-2 = 60.0%; p = 0.000). Further stratified analysis was performed for methodological differences, especially dosage, time of treatments, and time-point of outcome assessment. The meta-analysis of NS showed a significant difference in favor of RES treatment (SMD: 1.342; 95% CI: 1.089, 1.595; p = 0.000) with low heterogeneity (Q = 25.58; I-2 = 17.9%; p = 0.223). Conclusion: Generally, RES treatment showed an improvement in both pathological and behavioral outcomes in SAH animal models. The results of this study may provide a reference for preclinical and clinical studies in the future to some extent, with great significance for human health."

基金机构：National Natural Science Foundation of China [NSFC 81870927]; Natural Science Foundation Project of Chongqing Science and Technology Commission [cstc2019 jcyj-msxmX0239]

基金资助正文：Funding This study was supported by a grant from the National Natural Science Foundation of China (NSFC 81870927) and a grant from the Natural Science Foundation Project of Chongqing Science and Technology Commission (cstc2019 jcyj-msxmX0239).