Metabolic Syndrome-Related Kidney Injury: A Review and Update

作者全名："Lin, Lirong; Tan, Wei; Pan, Xianfeng; Tian, En; Wu, Zhifeng; Yang, Jurong"

作者地址："[Lin, Lirong; Tan, Wei; Tian, En; Wu, Zhifeng; Yang, Jurong] Chongqing Med Univ, Gener Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China; [Pan, Xianfeng] Chongqing Kaizhou Dist Peoples Hosp Chongqing, Dept Nephrol, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Gener Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000827719700001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：metabolic syndrome; chronic kidney disease; diagnosis; pathological characteristics; therapeutics

摘要："Metabolic syndrome (MetS) includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. The prevalence of MetS is 20-25%, which is an important risk factor for chronic kidney disease (CKD). MetS causes effects on renal pathophysiology, including glomerular hyperfiltration, RAAS, microalbuminuria, profibrotic factors and podocyte injury. This review compares several criteria of MetS and analyzes their differences. MetS and the pathogenesis of CKD includes insulin resistance, obesity, dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction. The intervention of MetS-related renal damage is the focus of this article and includes controlling body weight, hypertension, hyperglycemia, and hyperlipidemia, requiring all components to meet the criteria. In addition, interventions such as endoplasmic reticulum stress, oxidative stress, gut microbiota, body metabolism, appetite inhibition, podocyte apoptosis, and mesenchymal stem cells are reviewed."

基金机构：National Natural Science Foundation of China [81770682]; Basic and Frontier Research Program of Chongqing [cstc2017jcyjBX0014]; Chongqing Talent Program Project [cstc2021ycjh-bgzxm0090]

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81770682), the Basic and Frontier Research Program of Chongqing (cstc2017jcyjBX0014) and the Chongqing Talent Program Project (cstc2021ycjh-bgzxm0090)."