Toward an accurate mechanistic understanding of Wolbachia-induced cytoplasmic incompatibility

作者全名："Wang, Wei; Cui, Wen; Yang, Haitao"

作者地址："[Wang, Wei; Cui, Wen] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Yang, Haitao] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; [Yang, Haitao] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Yang, Haitao] Tianjin Int Joint Acad Biotechnol & Med, Tianjin, Peoples R China"

通信作者："Wang, W (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.; Yang, HT (通讯作者)，ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China.; Yang, HT (通讯作者)，ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China."

来源：ENVIRONMENTAL MICROBIOLOGY

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000827894100001

JCR分区：Q2

影响因子：5.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：　

摘要："Wolbachia are the most successful intracellular bacteria in arthropods. They can manipulate host reproduction to favour infected females, which transmit Wolbachia to their progeny and increase the presence of Wolbachia in the population. The reproductive alterations caused by Wolbachia include feminization, parthenogenesis, male killing and cytoplasmic incompatibility (CI), among which CI is the most common. CI leads to embryonic lethality when Wolbachia-infected males mate with uninfected females or those infected with an incompatible strain. This lethality can be rescued if females are infected with a compatible strain. Although CI was described in the 1960s and its connection to Wolbachia was made in the 1970s, the genes responsible for CI, called CI factors, were not identified until recently. Since then, significant progress has been made in understanding the molecular mechanism of CI using a combination of genetic, phylogenetic, biochemical and structural approaches. The detailed molecular mechanisms behind this fascinating endosymbiotic bacteria-induced phenotype have begun to emerge. Here, we summarize recent progress in understanding the molecular mechanism of CI, especially focusing on the recently solved CI factor structures and discussing what these new structures brought in terms of CI mechanism."

基金机构："CQMU Program for Youth Innovation in Future Medicine [W0073]; National Natural Science Foundation of China [81772204, 81902063]; Natural Science Foundation of Tianjin City [18JCJQJC48000]; Natural Science Program of Yuzhong District Science and Technology Commission [20190108]; cience and Technology Research Program of Chongqing Municipal Education Commission [KJQN20200442]; Science and Technology Commission of Shanghai Municipality [20XD1422900]; Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine; Shanghai Municipal Science and Technology Major Project [ZD2021CY001]"

基金资助正文："CQMU Program for Youth Innovation in Future Medicine, Grant/Award Number: W0073; National Natural Science Foundation of China, Grant/Award Numbers: 81772204, 81902063; Natural Science Foundation of Tianjin City, Grant/ Award Number: 18JCJQJC48000; Natural Science Program of Yuzhong District Science and Technology Commission, Grant/Award Number: 20190108; Science and Technology Research Program of Chongqing Municipal Education Commission, Grant/Award Number: KJQN20200442; Science and Technology Commission of Shanghai Municipality, Grant/ Award Number: 20XD1422900; Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine; Shanghai Municipal Science and Technology Major Project, Grant/ Award Number: ZD2021CY001"