Short and long-term effects of robot-assisted therapy on upper limb motor function and activity of daily living in patients post-stroke: a meta-analysis of randomized controlled trials

作者全名："Zhang, Liping; Jia, Gongwei; Ma, Jingxi; Wang, Sanrong; Cheng, Li"

作者地址："[Zhang, Liping; Jia, Gongwei; Wang, Sanrong] Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Ma, Jingxi] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, Chongqing 400013, Peoples R China; [Ma, Jingxi] Chongqing Key Lab Neurodegenerat Dis, Chongqing 400013, Peoples R China; [Cheng, Li] Chongqing Med Univ, Dept Hlth Management, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Cheng, L (通讯作者)，Chongqing Med Univ, Dept Hlth Management, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF NEUROENGINEERING AND REHABILITATION

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000828602800002

JCR分区：Q1

影响因子：5.1

年份：2022

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Stroke; Rehabilitation; Robot-assisted therapy; Upper limb; Meta-analysis

摘要："Objective To investigate the effect of robot-assisted therapy (RAT) on upper limb motor control and activity function in poststroke patients compared with that of non-robotic therapy. Methods We searched PubMed, EMBASE, Cochrane Library, Google Scholar and Scopus. Randomized controlled trials published from 2010 to nowadays comparing the effect of RAT and control treatment on upper limb function of poststroke patients aged 18 or older were included. Researchers extracted all relevant data from the included studies, assessed the heterogeneity with inconsistency statistics (I-2 statistics), evaluated the risk of bias of individual studies and performed data analysis. Result Forty-six studies were included. Meta-analysis showed that the outcome of the Fugl-Meyer Upper Extremity assessment (FM-UE) (SMD = 0.20, P = 0.001) and activity function post intervention was significantly higher (SMD = 0.32, P < 0.001) in the RAT group than in the control group. Differences in outcomes of the FM-UE and activity function between the RAT group and control group were observed at the end of treatment and were not found at the follow-up. Additionally, the outcomes of the FM-UE (SMD = 0.15, P = 0.005) and activity function (SMD = 0.32, P = 0.002) were significantly different between the RAT and control groups only with a total training time of more than 15 h. Moreover, the differences in outcomes of FM-UE and activity post intervention were not significant when the arm robots were applied to patients with severe impairments (FM-UE: SMD = 0.14, P = 0.08; activity: SMD = 0.21, P = 0.06) or when patients were provided with patient-passive training (FM-UE: SMD = - 0.09, P = 0.85; activity: SMD = 0.70, P = 0.16). Conclusion RAT has the significant immediate benefits for motor control and activity function of hemiparetic upper limb in patients after stroke compared with controls, but there is no evidence to support its long-term additional benefits. The superiority of RAT in improving motor control and activity function is limited by the amount of training time and the patients' active participation."

基金机构：Natural Science Foundation Project of Chongqing [cstc2019jcyj-msxmX0026]; Medical Scientific Research Projects Foundation of Chongqing [2018MSXM043]; National Natural Science Foundation of China [81900079]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0238]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2020MSXM036]

基金资助正文："The author disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Natural Science Foundation Project of Chongqing (Grant Number cstc2019jcyj-msxmX0026); the Medical Scientific Research Projects Foundation of Chongqing (Grant Number 2018MSXM043); the National Natural Science Foundation of China (Grant Number 81900079); Natural Science Foundation of Chongqing (Grant Number cstc2020jcyj-msxmX0238); Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (Grant Number 2020MSXM036)."