Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury

作者全名："Deng, Junhui; Wu, Zhifen; He, Yun; Lin, Lirong; Tan, Wei; Yang, Jurong"

作者地址："[Deng, Junhui; Wu, Zhifen; Lin, Lirong; Tan, Wei; Yang, Jurong] Chongqing Med Univ, Third Affiliated Hosp, Chongqing, Peoples R China; [He, Yun] Fifth Peoples Hosp Chongqing, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Third Affiliated Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000829646900001

JCR分区：Q1

影响因子：3.9

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：acute kidney injury; intrinsic renal cells; immune cells; interaction; microenvironment

摘要："A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to infiltrate through the release of chemokines, while the intrinsic cells promote macrophage polarity conversion, and the immune cells will promote various programmed deaths, phenotypic conversion and cycle arrest of the intrinsic cells, ultimately leading to renal impairment and fibrosis. In the complex and dynamic immune microenvironment of AKI, the bidirectional interaction between immune cells and intrinsic renal cells affects the prognosis of the kidney and the progression of fibrosis, and determines the ultimate fate of the kidney."

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