Main Pathological Changes of Benign Ureteral Strictures

作者全名："Tan, Jiang; Yu, Zhuoyuan; Ling, Xinyi; Qiu, Guoping; Yang, Xin; Tang, Yi; Yang, Dong; Yang, Mei; Gao, Fei"

作者地址："[Tan, Jiang; Qiu, Guoping; Yang, Mei] Chongqing Med Univ, Inst Neurosci, Coll Basic Med, Dept Anat, Chongqing, Peoples R China; [Yu, Zhuoyuan; Ling, Xinyi; Yang, Xin; Gao, Fei] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Tang, Yi] Chongqing Med Univ, Affiliated Hosp 1, Dept Pathol, Chongqing, Peoples R China; [Tang, Yi] Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, Chongqing, Peoples R China; [Yang, Dong] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Yang, M (通讯作者)，Chongqing Med Univ, Inst Neurosci, Coll Basic Med, Dept Anat, Chongqing, Peoples R China.; Gao, F (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000829889000001

JCR分区：Q1

影响因子：3.9

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ureteral stricture; histopathology; fibroblasts; leukocytes; collagen; hydronephrosis

摘要："ObjectiveTo identify the pathological classification of benign ureteral strictures according to the histological features and explore the relationship between various pathological types and inflammatory cells, fibroblasts, and collagen. Patients and MethodsThirty one specimens from patients diagnosed with ureteral strictures between 2013 and 2021 were included and classified according to the histopathological characteristics. The number of fibroblasts and inflammatory cells was counted, and the proportion of type I and type III collagen in ureteral stricture tissues was detected by picrosirius red staining. ResultsWe identified three types of benign ureteral strictures in 31 specimens: inflammatory cell infiltration (n = 10, 32%), fibroplasia (n = 14, 45%), and hyalinization (n = 7, 23%), with significant differences in obstruction history and hydronephrosis grades among the three types. The number of inflammatory cells (lymphocytes, neutrophils and eosinophils) was significantly lower in hyalinization ureteral strictures than in the other two types (p < 0.05). The number of foreign-body giant cells associated with foreign-body reactions increased significantly in suture-induced ureteral strictures (p < 0.05). Fibroplasia type had the largest number of fibroblasts, whereas the other two types had smaller numbers. The results of type I and III collagen analysis showed that type I and III collagen were the most abundant in hyalinization among all ureteral stricture types (p < 0.05). Compared to ureteral strictures, the content of type I and III collagen in atresia increased significantly (p < 0.05). ConclusionCommon pathological types of benign ureteral strictures include inflammatory cell infiltration, fibroplasia, and hyalinization. Changes in type I and III collagen, inflammatory cells, and fibroblasts in different pathological types may be related to the progression of ureteral strictures."

基金机构："National Natural Science Foundation of China [81672893, 81971230, 81671312]; Chongqing Science and Health joint project [2020GDRC007]; Senior Medical Talents Program of Chongqing [204216qn]; Reserve Talents Program for Academic Leaders of the First Affiliated Hospital of Chongqing Medical University [XKTS070]; Chongqing Medical University; First Affiliated Hospital of Chongqing Medical University; Chongqing Education Commission; Chongqing Health Committee"

基金资助正文："This work was supported by the National Natural Science Foundation of China to FG (No. 81672893) and MY (Nos. 81971230 and 81671312). Furthermore, it was supported by Chongqing Science and Health joint project (No. 2020GDRC007), Senior Medical Talents Program of Chongqing for Yong and Middle-aged (No. 204216qn) and Reserve Talents Program for Academic Leaders of the First Affiliated Hospital of Chongqing Medical University (No. XKTS070) to FG. This work was supported by the National Natural Science Foundation of China, Chongqing Medical University, the First Affiliated Hospital of Chongqing Medical University, Chongqing Education Commission, and Chongqing Health Committee. The sponsors had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication."