Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study

作者全名："Wang, Lin; Zhang, Chao; Liang, Hao; Zhou, Nian; Huang, Tianji; Zhao, Zenghui; Luo, Xiaoji"

作者地址："[Wang, Lin; Zhang, Chao; Liang, Hao; Zhou, Nian; Huang, Tianji; Zhao, Zenghui; Luo, Xiaoji] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing, Peoples R China; [Wang, Lin; Zhang, Chao; Liang, Hao; Zhou, Nian; Huang, Tianji; Zhao, Zenghui; Luo, Xiaoji] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China"

通信作者："Luo, XJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing, Peoples R China.; Luo, XJ (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000830176900001

JCR分区：Q1

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：polyunsaturated fatty acids; PUFA; bone mineral density-BMD; mendelian randomization; osteoporosis; omega; 3 fatty acids

摘要："BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD). MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy. ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: -0.0515; 95% confidence interval [CI]: -0.0911 to -0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: -0.0699; 95% CI: -0.1304 to -0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites. ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism."

基金机构：National Natural Science Foundation of China [81873998]

基金资助正文：Funding This study was funded by the National Natural Science Foundation of China (81873998).