Advanced glycation end products via skin autofluorescence as a new biomarker for major adverse cardiovascular events: A meta-analysis of prospective studies

作者全名："Chen, Qimou; Huang, Qiaojuan; Liu, Weiwei; Zhou, Xiaoli"

作者地址："[Chen, Qimou] Chongqing Med Univ, Dept Endocrinol & Metab, Univ Town Hosp, Middle Rd Univ Town 55, Chongqing, Peoples R China; [Huang, Qiaojuan; Liu, Weiwei; Zhou, Xiaoli] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Zhou, XL (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China."

来源：NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000830386000002

JCR分区：Q2

影响因子：3.9

年份：2022

卷号：32

期号：5

开始页：1083

结束页：1092

文献类型：Review

关键词：Advanced glycation end products; AGEs; Cardiovascular diseases; Skin autofluorescence

摘要："Aims: This meta-analysis aimed to systematically evaluate the prospective association between advanced glycation end products (AGEs) and major adverse cardiovascular events (MACE). Data synthesis: Prospective studies that reported the association of AGEs (measured by skin autofluorescence) with MACE were searched in PubMed and EMBASE from inception up to July 2021. Multivariable-adjusted hazard ratios (HRs) and their respective 95% confidence intervals (CIs) reflecting the risk of MACE associated with AGEs were determined using random-effects meta-analysis. Fourteen articles with sixteen items involving 79,389 participants were included. A significant association was found between AGEs and MACE (pooled HR: 1.54, 95% CI: 1.31-1.81, I-2 = 68%). Moreover, AGEs were associated with a significant increase in fatal cardiovascular disease (CVD) (HR: 1.88, 95% CI: 1.30-2.70) and nonfatal CVD (HR: 1.40, 95% CI: 1.12-1.74). The association between AGEs and MACE was also significant in patients with diabetes (HR: 1.88, 95% CI: 1.31-2.69) and kidney disease (HR: 1.50, 95% CI: 1.16-1.94). Conclusions: This meta-analysis indicates that higher levels of AGEs measured by skin autofluorescence are significantly correlated with a higher pooled risk of MACE, and AGEs are closely related to both nonfatal and fatal cardiovascular events. AGEs are a valuable biomarker for predicting the occurrence of MACE. (C) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved."

基金机构：　

基金资助正文：