Antitumor Potential and Structure Characterization of Polysaccharides From Lagotis brevituba Maxim in the Tibetan Plateau

作者全名："Gong, Ruixue; Cao, Weiguo; Huang, Haijun; Yu, Bao; Chen, Huan; Tao, Wei; Luorong, Quji; Luo, Juan; Zhang, Dan"

作者地址："[Gong, Ruixue; Cao, Weiguo; Huang, Haijun; Yu, Bao; Chen, Huan; Tao, Wei; Luorong, Quji; Luo, Juan; Zhang, Dan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing, Peoples R China"

通信作者："Zhang, D (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000831889000001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：isolation; purification; structure analysis; antioxidant; antitumor

摘要："This study purified two polysaccharides (LBMPs) from Lagotis brevituba Maxim in several steps. The chemical structure of LBMP-2 was determined by HPGPC, FT-IR, IC, H-1 and C-13 NMR, AFM, SEM, and TEM. The results show that LBMP-2 was mainly composed of GalA, and the Mw of LBMP-2 is 23.799 kDa. In addition, the antioxidant activity, and the antitumor activity in vitro and in vivo were studied. LBMP-2 has excellent antioxidant and antitumor capacity. The inhibition of tumor cell proliferation in vitro may result in the inhibition of aerobic respiration and glycolysis. Tumor growth inhibition in vivo may inhibit the expression of AMPK in tumors and enhance spleen function. Compared with conventional chemotherapy drug cyclophosphamide, LBMP-2 is less harmful to the body and safer. Therefore, LBMP-2 provides a potential source of antitumor drugs."

基金机构：Chongqing Technology Innovation and Application Development Project [cstc2020jscx-dxwtBX0054]

基金资助正文：Funding This work was supported by the Chongqing Technology Innovation and Application Development Project (grant no. cstc2020jscx-dxwtBX0054).