"Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study"

作者全名："Liu, Yue; Xia, Yin-Yin; Zhang, Ting; Yang, Yang; Cannon, Richard D.; Mansell, Toby; Novakovic, Boris; Saffery, Richard; Han, Ting-Li; Zhang, Hua; Baker, Philip N."

作者地址："[Liu, Yue; Yang, Yang; Zhang, Hua] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Liu, Yue; Xia, Yin-Yin] Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth & Management,Dept Occupat & Environm, Chongqing, Peoples R China; [Liu, Yue; Xia, Yin-Yin; Yang, Yang; Han, Ting-Li; Zhang, Hua] Chongqing Med Univ, Inst Life Sci, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China; [Zhang, Ting] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Cannon, Richard D.] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dept Oral Sci, Dunedin, New Zealand; [Mansell, Toby; Novakovic, Boris; Saffery, Richard] Murdoch Children92s Res Inst, Mol Immun, Melbourne, Vic, Australia; [Mansell, Toby; Novakovic, Boris; Saffery, Richard] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia; [Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing, Peoples R China; [Han, Ting-Li] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Med Biol Sci & Psychol, Leicester, England"

通信作者："Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China.; Han, TL; Zhang, H (通讯作者)，Chongqing Med Univ, Inst Life Sci, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynaecol, Chongqing, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000832868600001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：gestational diabetes mellitus; fatty acids; arachidonic acid; delta-5 desaturase activity; delta-9-18 desaturase activity

摘要："ObjectiveMaternal abnormal fatty acid desaturation has previously been linked to gestational diabetes mellitus (GDM). However, few studies have investigated this relationship longitudinally throughout pregnancy. In this study, we investigated the relationship between GDM and desaturase activities across the pregnancy trimesters. MethodsA total of 661 women (GDM = 189, non-GDM = 472) were selected from the Complex Lipids in Mothers and Babies (CLIMB) cohort study. Clinical information and maternal serum were collected at 11-14, 22-28, and 32-34 weeks of gestation. Totally, 20 serum fatty acids were quantified using gas chromatography-mass spectrometry (GC-MS) analysis at each timepoint. Polyunsaturated fatty acid (PUFA) product-to-precursor ratios were used to estimate desaturase and elongase activities including delta-5 desaturase, delta-6 desaturase, stearoyl-CoA desaturase, and elongase. ResultsAfter adjusting for major potential confounders including maternal age, BMI, primiparity, smoking, and alcohol consumption, we observed a significant increase in the levels of gamma-linolenic acid (GLA) and eicosatrienoic acid (DGLA) in the first trimester of women with GDM, whereas GLA and DGLA were reduced in the third trimester, when compared to the non-GDM group. Arachidonic acid (AA) showed an upward trend in the GDM group throughout pregnancy. Estimated delta-6 desaturase and delta-5 desaturase activity were elevated in the first trimester (OR = 1.40, 95% CI 1.03-1.91; OR = 0.56, 95% CI 0.32-0.96) but attenuated in the third trimester (OR = 0.78, 95% CI 0.58-1.07; OR = 2.64, 95% CI 1.46-4.78) in GDM pregnancies, respective to controls. Estimated delta-9-18 desaturase activity (OR = 3.70, 95% CI 1.49-9.19) was increased in women with GDM in later pregnancy. ConclusionsOur study highlights the potential importance of fatty acid desaturase activities, particularly estimated delta-5 desaturase and delta-9-18 desaturase in the pathophysiology of GDM. These findings may have applications for the early diagnosis and management of GDM."

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