Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents

作者全名："Jiang, Yuanliang; Qin, Mengchang; Teng, Teng; Li, Xuemei; Yu, Ying; Wang, Jie; Wu, Hongyan; He, Yuqian; Zhou, Xinyu; Xie, Peng"

作者地址："[Jiang, Yuanliang; Li, Xuemei; Wang, Jie; Wu, Hongyan; Zhou, Xinyu] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Jiang, Yuanliang; Qin, Mengchang; Teng, Teng; Li, Xuemei; Yu, Ying; Wang, Jie; Wu, Hongyan; He, Yuqian; Zhou, Xinyu; Xie, Peng] Chongqing Med Univ, Natl Hlth Commiss NHC Key Lab Diag & Treatment Bra, Affiliated Hosp 1, Chongqing, Peoples R China; [Qin, Mengchang; Teng, Teng; Yu, Ying; He, Yuqian; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhou, XY; Xie, P (通讯作者)，Chongqing Med Univ, Natl Hlth Commiss NHC Key Lab Diag & Treatment Bra, Affiliated Hosp 1, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000833970700001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：major depressive disorder; children and adolescents; sex specific; biomarker; metabolomics; plasma

摘要："BackgroundChildren and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD. MethodsHere, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry. ResultsThe metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related and 53 female-related differential metabolites. Compared with HCs, both male and female subjects with MDD displayed four significantly altered pathways. Notably, biliverdin was selected as an independent diagnostic male-specific biomarker with an area under the receiver operating characteristic curve of 0.966, and phosphatidylcholine (10:0/14:1) was selected as a female-specific biomarker, achieving an area under the curve (AUC) of 0.957. ConclusionThis metabolomics study may aid in the development of a plasma-based test for the diagnosis of male and female children and adolescents with MDD, as well as give new insight into the pathophysiology of sex differences in children and adolescents with MDD."

基金机构：National Key Research and Development Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; Natural Science Foundation Project of China [81820108015]

基金资助正文："This research was supported by the National Key Research and Development Program of China (Grant no. 2017YFA0505700), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (Grant no. 2019PT320002), and the Natural Science Foundation Project of China (Grant no. 81820108015)."