The Role of T Helper 22 Cells in Dermatological Disorders

作者全名："Pan, Yu; Du, Dan; Wang, Lian; Wang, Xiaoyun; He, Gu; Jiang, Xian"

作者地址："[Pan, Yu; Du, Dan; Wang, Lian; Wang, Xiaoyun; He, Gu; Jiang, Xian] Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu, Peoples R China; [Pan, Yu] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Wang, Xiaoyun; He, Gu; Jiang, Xian] Sichuan Univ, West China Hosp, China Inst Inflammat & Immunol CIII, Frontiers Sci Ctr Dis Related Mol Network,Lab Derm, Chengdu, Peoples R China; [Wang, Xiaoyun; He, Gu; Jiang, Xian] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China"

通信作者："He, G; Jiang, X (通讯作者)，Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu, Peoples R China.; He, G; Jiang, X (通讯作者)，Sichuan Univ, West China Hosp, China Inst Inflammat & Immunol CIII, Frontiers Sci Ctr Dis Related Mol Network,Lab Derm, Chengdu, Peoples R China.; He, G; Jiang, X (通讯作者)，Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000834055200001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Th22 cells; IL-22; skin; inflammation; keratinocyte

摘要："T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-gamma or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway."

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