Blood-brain barrier penetrating carbon dots with intrinsic anti-inflammatory and drug-loading properties

作者全名："Zhang, Xianming; Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao"

作者地址："[Zhang, Xianming; Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Zhang, Xianming; Deng, Tao; Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Pharmacodynam Evaluat Engn Technol Res, Chongqing 400016, Peoples R China"

通信作者："Deng, T; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：BIOMATERIALS ADVANCES

ESI学科分类：　

WOS号：WOS:000834074400005

JCR分区：N/A

影响因子：N/A

年份：2022

卷号：139

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Anti-inflammatory replenisher; Bioimaging; Blood -brain barrier; Carbon dots; Visualized drug carrier

摘要："The blood-brain barrier (BBB) is the major obstacle limiting the reach of therapeutic drugs into the brain. Herein, an aspirin-based anti-inflammatory replenisher (aspCD) was fabricated by carbonizing aspirin to deliver drugs into the brain visually. The as-prepared aspCD combined the BBB-penetrating and anti-inflammatory effects of aspirin with the fluorescent and drug-loading properties of carbon dots (CDs), thereby delivering therapeutic drugs into the brain and acting as imaging agent as well as anti-inflammatory replenisher. In vivo experiments of mice and zebrafish revealed that fluorescence aspCD could effectively penetrate BBB. In vitro and in vivo in-flammatory models demonstrated that aspCD could be regarded as an excellent anti-inflammatory replenisher. In addition, as a functional carrier, aspCD was proved to be capable of loading drugs with different polarity. In summary, carbonization of active precursors (therapeutic drugs) into CDs could be a promising strategy to achieve the loading and visualization of drugs as well as the retainment of their biological activities."

基金机构："China Postdoctoral Science Foundation [2019M653356]; Chongqing Postdoctoral Science Foundation [cstc2019jcyjbshX0060]; Introduction Teachers Foundation of Chongqing Medical University [YXY2018BSH1]; Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission [CXQT20012]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0090]"

基金资助正文："This work was financially supported by the China Postdoctoral Science Foundation (2019M653356), Chongqing Postdoctoral Science Foundation (cstc2019jcyjbshX0060), the Introduction Teachers Foundation of Chongqing Medical University (YXY2018BSH1), the Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission (No. CXQT20012), and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0090)."