Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma

作者全名："Wei, Zongjie; Zhang, Fan; Ma, Xin; He, Weiyang; Gou, Xin; Zhang, Xu; Xie, Yongpeng"

作者地址："[Wei, Zongjie; He, Weiyang; Gou, Xin; Xie, Yongpeng] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd,Yuzhong Dist, Chongqing 400016, Peoples R China; [Zhang, Fan; Ma, Xin; Zhang, Xu] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Urol, Beijing, Peoples R China"

通信作者："Xie, YP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, 1 Youyi Rd,Yuzhong Dist, Chongqing 400016, Peoples R China."

来源：TRANSLATIONAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000835500600001

JCR分区：Q1

影响因子：5

年份：2022

卷号：23

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Renal cell carcinoma; Red blood cell distribution width; Biomarker; Prognosis

摘要："Objective: This study aimed to explore the prognostic value of preoperative red blood cell distribution width (RDW) in patients with metastatic renal cell carcinoma (mRCC). Methods: Clinicopathological data of 230 patients with mRCC treated at the First Affiliated Hospital of Chongqing Medical University and the Chinese PLA General Hospital from January 2008 to December 2018 were retrospectively analyzed. Patients were stratified according to the optimal cut-off value of RDW calculated using X-tile software. The prognostic value of RDW was analyzed using the Kaplan-Meier curve with log-rank test and univariate and multivariate Cox proportional hazards models. Results: A total of 230 patients were included. The optimal cut-off value of RDW obtained using X-tile software was 13.1%. The median Progression-free survival (PFS) and Overall survival (OS) of all populations were 12.06 months (IQR: 4.73-36.9) and 32.20 months (IQR: 13.73-69.46), respectively. Kaplan-Meier curves showed that patients with high RDW had worse PFS and OS than those with low RDW (median PFS of 9.7 months vs. 17.9 months, P = 0.002, and median OS of 27.8 months vs. 45.1 months, P = 0.012, respectively). Multivariate analysis showed that RDW was an independent risk factor for PFS (HR: 1.505; 95% CI: 1.111-2.037; P = 0.008) and OS (HR: 1.626; 95% CI: 1.164-2.272; P = 0.004) in mRCC after cytoreductive nephrectomy. Conclusion: Preoperative RDW was independently associated with PFS and OS in patients with mRCC and may be a potential predictor of survival outcomes in mRCC."

基金机构：Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0717]

基金资助正文：The data used to support the findings of this study are included within the article. This work was supported by the Natural Science Foundation of Chongqing [Grant No. cstc2020jcyj-msxmX0717] .