Rodents on a high-fat diet born to mothers with gestational diabetes exhibit sex-specific lipidomic changes in reproductive organs

作者全名："Wang, Andi; Luo, Baiyu; Chen, Zhu; Xia, Yinyin; Chen, Chang; Qi, Hongbo; Baker, Philip N.; Saffery, Richard; Han, Ting-Li; Zhang, Hua"

作者地址："[Wang, Andi; Luo, Baiyu; Qi, Hongbo; Zhang, Hua] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Wang, Andi; Luo, Baiyu; Han, Ting-Li] Chongqing Med Univ, Chongqing Key Lab Translat Med Major Metab Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Chen, Zhu] Army Med Univ, Xin Qiao Hosp, Dept Obstet & Gynecol, Med Coll 2, Chongqing 400037, Peoples R China; [Xia, Yinyin] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China; [Chen, Chang] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Med Biol Sci & Psychol, Leicester, Leics, England; [Saffery, Richard] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic, Australia; [Han, Ting-Li] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing 400037, Peoples R China"

通信作者："Zhang, H (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Translat Med Major Metab Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing 400037, Peoples R China."

来源：ACTA BIOCHIMICA ET BIOPHYSICA SINICA

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000836003000014

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：54

期号：5

开始页：736

结束页：747

文献类型：Article

关键词：maternal GDM; mice offspring; metabolomics; hormone; insulin signaling

摘要："Maternal gestatonal diabetes mellitus (GDM) and offspring high-fat diet (HFD) have been shown to have sex-specific detrimental effects on the health of the offspring. Maternal GDM combined with an offspring HFD alters the lipidomic profiles of offspring reproductive organs with sex hormones and increases insulin signaling, resulting in offspring obesity and diabetes. The pre-pregnancy maternal GDM mice model is established by feeding maternal C57BL/6 mice and their offspring are fed with either a HFD or a low-fat diet (LFD). Testis, ovary and liver are collected from offspring at 20 weeks of age. The lipidomic profiles of the testis and ovary are characterized using gas chromatography-mass spectrometry. Male offspring following a HFD have elevated body weight. In reproductive organs and hormones, male offspring from GDM mothers have decreased testes weights and testosterone levels, while female offspring from GDM mothers show increased ovary weights and estrogen levels. Maternal GDM aggravates the effects of an offspring HFD in male offspring on the AKT pathway, while increasing the risk of developing inflammation when expose to a HFD in female offspring liver. Testes are prone to the effect of maternal GDM, whereas ovarian metabolite profiles are upregulated in maternal GDM and downregulated in offspring following an HFD. Maternal GDM and an offspring HFD have different metabolic effects on offspring reproductive organs, and PUFAs may protect against detrimental outcomes in the offspring, such as obesity and diabetes."

基金机构："National Natural Science Foundation of China [81971406, 81771607, 81871185, 81901507, 81961128004]; 111 Project [Yuwaizhuan (2016) 32]; Chongqing Health Commission [2018ZDXM024]; Chongqing Science & Technology Commission [2021MSXM121, 2020MSXM101, cstc2021jcyj-msxmX0213]; Chongqing Health Commission"

基金资助正文："This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81971406, 81771607, 81871185, 81901507, 81961128004), the 111 Project (No. Yuwaizhuan (2016) 32), the Chongqing Health Commission (No. 2018ZDXM024), and the Chongqing Health Commission and Chongqing Science & Technology Commission (Nos. 2021MSXM121, 2020MSXM101 and cstc2021jcyj-msxmX0213)."