Genome-wide association study of SARS-CoV-2 infection in Chinese population

作者全名："Fan, Jie; Long, Quan-Xin; Ren, Ji-Hua; Chen, Hao; Li, Meng-Meng; Cheng, Zheng; Chen, Juan; Zhou, Li; Huang, Ai-Long"

作者地址："[Fan, Jie; Chen, Hao; Li, Meng-Meng; Cheng, Zheng; Zhou, Li] Chongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Res Ctr Med & Social Dev, Dept Epidemiol,Sch Publ Hlth & Management, Chongqing 400016, Peoples R China; [Fan, Jie] Nanan Dist Ctr Dis Control & Prevent, Chongqing, Peoples R China; [Long, Quan-Xin; Ren, Ji-Hua; Chen, Juan; Huang, Ai-Long] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Chinese Minist Educ, Room 617,Coll Life Sci Bldg,1 YixueYuan Rd, Chongqing 400016, Peoples R China; [Chen, Juan] Chongqing Med Univ, Key Lab Lab Med Diagnost, Chinese Minist Educ, Chongqing, Peoples R China"

通信作者："Zhou, L (通讯作者)，Chongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Res Ctr Med & Social Dev, Dept Epidemiol,Sch Publ Hlth & Management, Chongqing 400016, Peoples R China.; Chen, J; Huang, AL (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Chinese Minist Educ, Room 617,Coll Life Sci Bldg,1 YixueYuan Rd, Chongqing 400016, Peoples R China.; Chen, J (通讯作者)，Chongqing Med Univ, Key Lab Lab Med Diagnost, Chinese Minist Educ, Chongqing, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000836128000001

JCR分区：Q2

影响因子：4.5

年份：2022

卷号：41

期号：9

开始页：1155

结束页：1163

文献类型：Article

关键词：COVID-19; SARS-CoV2; GWAS; Severity; Susceptibility

摘要："Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 x 10(-6)). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 x 10(-5)) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options."

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