The role of children in household transmission of COVID-19: a systematic review and meta-analysis

作者全名："Chen, Feifan; Tian, Yan; Zhang, Lixin; Shi, Yuan"

作者地址："[Chen, Feifan; Tian, Yan; Zhang, Lixin; Shi, Yuan] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol, Minist Educ,Key Lab Child Dev & Disorders,China In, Chongqing 400014, Peoples R China; [Shi, Yuan] Childrens Hosp Chongqing Med Univ, Chongqing 400014, Peoples R China"

通信作者："Shi, Y (通讯作者)，Childrens Hosp Chongqing Med Univ, Chongqing 400014, Peoples R China."

来源：INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000836319700007

JCR分区：Q1

影响因子：8.4

年份：2022

卷号：122

期号：　

开始页：266

结束页：275

文献类型：Review

关键词：COVID-19; SARS-CoV-2; Household transmission; Child

摘要："Objectives: To explore household transmissibility of SARS-CoV-2 in children in new-variants dominating periods.Methods: Through retrieval in PubMed and Embase, studies were included in two parts: meta-analysis of the household secondary attack rate (SAR) and case analysis of household pediatric infections.Results: A total of 95 articles were included: 48 for meta-analysis and 47 for case analysis. Pediatric COVID-19 only comprised a minority of the household transmission. The total pooled household SAR of child index cases and contacts were 0.20 (95% confidence interval [CI]: 0.15-0.26) and 0.24 (95% CI: 0.18-0.30). Lower household transmissibility was reported in both child index cases and contacts than in adults (relative risk [RR] = 0.64, 95% CI: 0.50-0.81; RR = 0.74, 95% CI: 0.64-0.85). Younger children were as susceptible as the older children (RR = 0.89, 95% CI: 0.72-1.10). Through subgroup analyses of different variants and periods, increased household SAR was observed in children (Wild: 0.20; Alpha: 0.42; Delta: 0.35; Omicron: 0.56), and no significant difference was found in household SAR between children and adults when new variants dominated. Conclusion: Although children were found not to be dominant in the household transmission, their transmissibility of SARS-CoV-2 appeared to be on the rise as new variants emerged.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )"

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