Reference intervals of 14 biochemical markers for children and adolescence in China: the PRINCE study

作者全名："Peng, Xiaoxia; Peng, Yaguang; Zhang, Chuanbao; Zhao, Min; Yang, Hongling; Cao, Sancheng; Li, Guixia; Jiang, Yongmei; Guo, Zhenxin; Chen, Dapeng; Xu, Jin; Chen, Hongbing; Xiang, Yun; Mu, Runqing; Zeng, Jie; Shen, Ying; Wang, Yan; Li, Qiliang; Hu, Lixin; Ren, Na; Cai, Yanying; Zhang, Wei; Ma, Jie; Yan, Ruohua; Chen, Wenxiang; Song, Wenqi; Ni, Xin"

作者地址："[Chen, Wenxiang] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Clin Labs, Natl Ctr Childrens Hlth, 1 Dahua Rd, Beijing 100730, Peoples R China; [Song, Wenqi] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Clin Lab Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China; [Ni, Xin] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, 56 Nanlishi Rd, Beijing 100045, Peoples R China; [Peng, Xiaoxia; Peng, Yaguang; Shen, Ying; Wang, Yan; Li, Qiliang; Hu, Lixin; Ren, Na; Cai, Yanying; Zhang, Wei; Ma, Jie; Yan, Ruohua] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Beijing, Peoples R China; [Zhang, Chuanbao; Zeng, Jie] Natl Ctr Clin Labs NCCL, Beijing, Peoples R China; [Zhao, Min; Mu, Runqing] China Med Univ, Hosp 1, Shenyang, Liaoning, Peoples R China; [Yang, Hongling] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China; [Cao, Sancheng] Xian Childrens Hosp, Xian, Shaanxi, Peoples R China; [Li, Guixia] Childrens Hosp Hebei Prov, Shijiazhuang, Hebei, Peoples R China; [Jiang, Yongmei] Sichuan Univ, West China Univ Hosp 2, Chengdu, Sichuan, Peoples R China; [Guo, Zhenxin] Zhengzhou Childrens Hosp, Henan Childrens Hosp, Zhengzhou, Henan, Peoples R China; [Chen, Dapeng] Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China; [Xu, Jin] Fudan Univ, Childrens Hosp, Shanghai, Peoples R China; [Chen, Hongbing] Nanjing Med Univ, Childrens Hosp, Nanjing, Jiangsu, Peoples R China; [Xiang, Yun] Wuhan Women & Children Med Care Ctr, Wuhan, Hubei, Peoples R China"

通信作者："Chen, WX (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Clin Labs, Natl Ctr Childrens Hlth, 1 Dahua Rd, Beijing 100730, Peoples R China.; Song, WQ (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Clin Lab Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China.; Ni, X (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, 56 Nanlishi Rd, Beijing 100045, Peoples R China."

来源：CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000837047200001

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：60

期号：10

开始页：1627

结束页：1639

文献类型：Article

关键词：biochemical marker; children and adolescence; China; reference interval

摘要："Objectives The Pediatric Reference Intervals in China (PRINCE) was initiated to establish the reference intervals (RIs) of Chinese children, as well as to make it possible to compare the variability of biochemical markers among countries internationally. Methods Healthy participants, aged up to 20 years, from 11 provinces across China, were enrolled in PRINCE and according to a standard screening procedure, that included a questionnaire survey, physical examinations and laboratory tests. Fasting venous blood specimens were collected. All serum specimens were analyzed with Cobas C702 in the center laboratory, i.e. clinical laboratory of Beijing Children's Hospital, with certified qualification (ISO15189). The nonparametric method recommended by Clinical Laboratory Standards Institute guidelines, was used to calculate the age- and sex-specified RIs. Results Among the 15,150 participants enrolled, 12,352 children (6,093 males and 6,259 females) were included to calculate RIs. The RIs for total protein, albumin, globulin, calcium, phosphate, potassium, sodium, chlorine, alkaline phosphatase, gamma-glutamyl transpeptadase, alanine aminotransferase, aspartate aminotransferase, creatinine and urea were established by age- or sex-partitions. Most biochemical markers displayed larger variability and higher dispersion during the periods between 28 days and 1 year old, and included 4-6 age partitions commonly during 1 to <20 years old. In addition, differences of RIs between sexes usually occurs around the initiation of puberty at 12-13 years old. Conclusions The age- and sex-specified RIs of 14 biochemical markers in PRINCE study can provide a solid reference, which will be transferred into relevant RIs for other clinical laboratory's platforms according to the CLSI guidelines."

基金机构："Medical hospital authority, National Health Commission of the People's Republic of China [2017374]"

基金资助正文："The grand from Medical hospital authority, National Health Commission of the People's Republic of China (No. 2017374)."