Sex differences of language abilities of preschool children with autism spectrum disorder and their anatomical correlation with Broca and Wernicke areas

作者全名："Zhang, Yun; Qin, Bin; Wang, Longlun; Chen, Jie; Cai, Jinhua; Li, Tingyu"

作者地址："[Zhang, Yun; Qin, Bin; Wang, Longlun; Cai, Jinhua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Minist Educ,Childrens Hosp,Key Lab Child Dev & Dis, Chongqing, Peoples R China; [Zhang, Yun; Qin, Bin] Acad Chongqing Med Univ, Chongqing Engn Res Ctr Clin Big Data & Drug Evalua, Med Data Sci, Chongqing, Peoples R China; [Chen, Jie; Li, Tingyu] Chongqing Med Univ, Children Nutr Res Ctr, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Cai, JH (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Minist Educ,Childrens Hosp,Key Lab Child Dev & Dis, Chongqing, Peoples R China.; Li, TY (通讯作者)，Chongqing Med Univ, Children Nutr Res Ctr, Childrens Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000837135900001

JCR分区：Q1

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：autism spectrum disorder; language; preschool children; Broca area; Wernicke area

摘要："ObjectivePeople with autism spectrum disorder (ASD) often have language difficulties. This study focuses on whether there are sex differences in language ability in children with ASD and aims to analyze whether such differences may arise from developmental imbalances in the anatomical structures of Broca and Wernicke areas. MethodsThe language development quotient (DQ) scores of Gesell Developmental Scale (GDS) and the scores of language communication of Childhood Autism Rating Scale (CARS) were used to judge the language ability, and the FREESURFER software extracted the anatomical structures of Broca and Wernicke areas on 3DT1 sequences. We analyzed the correlation between the anatomical structure of Broca/Wernicke areas and language abilities assessments. ResultsThe study initially included 44 cases of ASD, with 36 males (81.8 %) and 8 females (18.2%), and the age range was 24-72 months. Males have better language abilities than females. Specifically, the GDS verbal DQ of males was significantly higher than that of females (56.50 +/- 18.02 vs. 29.23 +/- 6.67, p < 0.001). Broca thickness-L was positively correlated with verbal DQ scores in GDS (r = 0.382, p = 0.011) and lower than grade 2 and 3 on the CARS verbal communication grade 4 (5.76 +/- 0.17 vs. 6.21 +/- 0.30 and 6.11 +/- 0.35), with statistically significant differences between groups (p < 0.05). ConclusionThere were sex differences in the language abilities of preschoolers with ASD, which may be due to an imbalance development of certain structures in Broca and Wernicke areas, especially Broca area."

基金机构："National Nature Science of Foundation of China [81770526, 81771223]; Intelligent Medicine Research Project of Chongqing Medical University"

基金资助正文：Funding This study was funded by the National Nature Science of Foundation of China (81770526 and 81771223) and Intelligent Medicine Research Project of Chongqing Medical University in 2020 (Grant No. ZHYX202030) for data collection.