Evaluating the value of superoxide dismutase in anti-MDA5-positive dermatomyositis associated with interstitial lung disease

作者全名："Huang, Wenhan; Chen, Dandan; Wang, Zhongjie; Ren, Feifeng; Luo, Lei; Zhou, Jun; Huang, Dongmei; Tian, Mengxue; Chen, Hong; Tang, Lin"

作者地址："[Huang, Wenhan; Chen, Dandan; Wang, Zhongjie; Ren, Feifeng; Luo, Lei; Zhou, Jun; Huang, Dongmei; Tian, Mengxue; Tang, Lin] Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Chen, Hong] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Tang, L (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：RHEUMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000839500500001

JCR分区：Q1

影响因子：5.5

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：anti-MDA5-positive DM; anti-Ro-52 antibodies; interstitial lung disease; serum ferritin; superoxide dismutase

摘要："Objective This study aimed to investigate the relationship between serum superoxide dismutase (SOD) and interstitial lung disease (ILD) among patients with anti-melanoma differentiation-associated gene 5 antibody (MDA5)-positive DM. Method In this retrospective study, serum SOD of 90 health check-ups were tested in our hospital. A total of 94 hospitalized patients with anti-MDA5-positive DM had ILD. Their serum SOD, serum ferritin and autoantibody levels were determined and lung high-resolution CT was performed. Results The serum SOD level was significantly lower in the anti-MDA5-positive DM group compared with the control group. The SOD level was significantly lower in patients positive for both anti-MDA5 antibodies and anti-Ro-52 antibodies than in those positive for only anti-MDA5 antibodies before treatment. The SOD level was significantly lower in the higher serum ferritin group compared with the lower serum ferritin group before treatment. After treatment, the serum SOD level decreased in patients with exacerbation of ILD, while it increased in those with alleviated ILD. The SOD level was significantly lower in the death group than in the survival group before treatment. Conclusions In patients with anti-MDA5-positive DM, the low SOD level before treatment indicated the presence of oxidative stress in the disease; the serum SOD level was affected by anti-Ro-52 antibodies and ferritin; there is a close relationship between serum SOD level and ILD among patients with anti-MDA5-positive DM, suggesting that SOD might serve as an effective indicator to evaluate the changes in ILD in these patients; and the low SOD level is an important indicator of poor prognosis in these patients, which deserves attention from rheumatologists."

基金机构：National Natural Science Foundation of China [81771738]

基金资助正文：This work was supported by grant 81771738 from the National Natural Science Foundation of China.