In vivo photoacoustic image-guided tumor photothermal therapy and real-time temperature monitoring using a core-shell polypyrrole@CuS nanohybrid

作者全名："Cao, Yang; Chen, Ziqun; Ran, Haitao"

作者地址："[Cao, Yang; Chen, Ziqun; Ran, Haitao] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China"

通信作者："Cao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China."

来源：NANOSCALE

ESI学科分类：PHYSICS

WOS号：WOS:000839599900001

JCR分区：Q1

影响因子：6.7

年份：2022

卷号：14

期号：33

开始页：12069

结束页：12076

文献类型：Article

关键词：　

摘要："Near-infrared (NIR) laser triggered theranostic platforms are increasingly used in clinical nanomedicine applications. In this work, a core-shell composite consisting of polypyrrole (PPy) coated copper sulfide (CuS) nanospheres with high photothermal efficiency and good photostability has been fabricated via a facile interfacial polymerization. The PPy@CuS nanohybrid had a hydrodynamic diameter of 58.5 nm with a CuS core and PPy shell and exhibited strong optical absorption and photon-to-heat conversion in the NIR region, leading to a sufficient photohyperthermic effect under irradiation with a 808 nm continuous wave laser. In vivo studies showed that the Ppy@CuS nanohybrids produced significant photoacoustic signals and exhibited remarkable photothermal therapeutic efficacy. Furthermore, the core-shell composites exhibited improved temperature elevation and photostability. The temperature-induced changes can be detected and monitored using photoacoustic imaging, thus allowing the control of the thermal dose while minimizing photothermal damage to surrounding healthy tissues. In summary, this study demonstrates that this novel platform could potentially be used for photoacoustic image-guided photothermal therapy and real-time temperature monitoring in cancer theranostics."

基金机构：National Natural Science Foundation of China; China Postdoctoral Science Foundation; Chongqing Postdoctoral Science Foundation; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This work was supported by the National Natural Science Foundation of China, China Postdoctoral Science Foundation funded projects, Chongqing Postdoctoral Science Foundation funded project and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University. The authors gratefully acknowledge the assistance and guidance of Prof. Stanislav Y. Emelianov and Dr Diego S. Dumani from Georgia Institute of Technology."