Selenium Intake and its Interaction with Iron Intake Are Associated with Cognitive Functions in Chinese Adults: A Longitudinal Study

作者全名："Jiang, Ke; Xie, Changxiao; Li, Zhourong; Zeng, Huan; Zhao, Yong; Shi, Zumin"

作者地址："[Jiang, Ke; Xie, Changxiao; Li, Zhourong; Zeng, Huan; Zhao, Yong] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Jiang, Ke; Xie, Changxiao; Li, Zhourong; Zeng, Huan; Zhao, Yong] Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing 400016, Peoples R China; [Jiang, Ke; Xie, Changxiao; Li, Zhourong; Zeng, Huan; Zhao, Yong] Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing 400016, Peoples R China; [Zhao, Yong] Chongqing Med Univ, Chongqing Key Lab Child Nutr & Hlth, Childrens Hosp, Chongqing 400014, Peoples R China; [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar"

通信作者："Zhao, Y (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Child Nutr & Hlth, Childrens Hosp, Chongqing 400014, Peoples R China."

来源：NUTRIENTS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000839758800001

JCR分区：Q1

影响因子：5.9

年份：2022

卷号：14

期号：15

开始页：　

结束页：　

文献类型：Article

关键词：selenium intake; cognitive function; iron intake; Chinese; adults; nutrition survey

摘要："Studies on the relation between selenium intake and cognitive function are inconclusive. This study aimed to examine the associations between dietary selenium intake and cognitive function among Chinese adults and tested the interaction effect of selenium intake and iron intake on cognition. Data from 4852 adults aged 55 years and above who attended the 1991-2006 China Health and Nutrition Survey (CHNS) were used. Cognitive function was assessed through face-to-face interviews in 1997, 2000, 2004, and 2006. A 3-day, 24-hour recall was used to collect dietary selenium intake. Multivariable mixed linear regression and logistic regression were used in the analyses. In fully adjusted regression models, the regression coefficients (95% confidence interval) were 0.00, 0.29 (-0.12-0.70), 0.26 (-0.18-0.70), and 0.50 (0.02-0.97) across the quartiles of selenium intake. In the subgroup analysis, the positive association between selenium intake and cognitive function was only observed in the participants who live in the southern region but not those in the northern region. The selenium-intake-to-iron-intake ratio was inversely associated with low global cognition scores. Furthermore, only those with a normal BMI had a positive association between selenium and cognition. In conclusion, high selenium intake was linked to better cognitive function and a lower risk of cognition decline in Chinese adults among those with low iron intake. A substantial interaction was found between selenium intake and BMI or region."

基金机构：Chongqing Nutrition Society [2019001]

基金资助正文："This project was funded by the project of Chongqing Nutrition Society (2019001)-Research on dietary selenium intake and its relationship with hypertension and diabetes in middle-aged and older adults in Jiangjin Chongqing. The funders had no role in the design, analysis, data interpretation, and publication of the findings."