Bone morphogenetic protein-9 maybe an important factor which improves insulin resistance in PCOS

作者全名："Yuan, Xiaoying; Huang, Qi; Li, Jing; Yao, Qu; Zhang, Han; Wang, Qian; Zhang, Lin; Zhang, Ying; Yang, Gangyi; Li, Ling; Liao, Xin"

作者地址："[Yuan, Xiaoying; Li, Jing; Yao, Qu; Zhang, Han; Wang, Qian; Zhang, Lin; Zhang, Ying; Liao, Xin] Zunyi Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Zunyi 563000, Guizhou, Peoples R China; [Huang, Qi] Zunyi Med Univ, Affiliated Hosp, Dept Nucl Med, Zunyi, Guizhou, Peoples R China; [Yang, Gangyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China; [Li, Ling] Chongqing Med Univ, Minist Educ, Coll Lab Med, Key Lab Diagnost Med, Chongqing, Peoples R China; [Li, Ling] Chongqing Med Univ, Coll Lab Med, Dept Clin Biochem, Chongqing, Peoples R China"

通信作者："Liao, X (通讯作者)，Zunyi Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Zunyi 563000, Guizhou, Peoples R China.; Yang, GY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China."

来源：GYNECOLOGICAL ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000840048300001

JCR分区：Q3

影响因子：2

年份：2022

卷号：38

期号：9

开始页：781

结束页：789

文献类型：Article

关键词：Bone morphogenetic protein-9; polycystic ovary syndrome; insulin resistance

摘要："Background Polycystic ovary syndrome (PCOS) is closely related to insulin resistance (IR). Bone morphogenetic protein-9 (BMP-9) plays an important role in maintaining glucose homeostasis, but an association between BMP-9 and PCOS has not been reported. Here, we report the changes in BMP-9 and the influence of this protein on IR in PCOS. Methods 57 PCOS patients were selected (among them 25 received interventional treatment with exenatide (EX) for 3 months, and 32 received no treatment). 22 normal control individuals and 30 IR patients were also recruited. We evaluated IR with the euglycaemic-hyperinsulinaemic clamp (EHC) technique. IR and the glucose metabolism rate were assessed by EHC and [3-3H]glucose tracer experiments. We determined the protein expression levels of BMP-9, p-AKT (protein kinase B) and androgen receptor in the ovaries and liver by Western blotting. Results We found that circulating BMP-9 levels were significantly decreased in PCOS with IR patients. Circulating BMP-9 levels and p-AKT levels were decreased in HFD and PCOS rats and increased after MF and EX treatment. The glucose infusion rate, glucose disappearance rate and suppression of hepatic glucose production decreased in the HFD and PCOS groups, the opposite results were found for HGP. AR protein expression levels increased in the HFD and PCOS groups and decreased in the MF and EX groups. Conclusions Our study results suggest that BMP-9 is an independent factor that influences IR in PCOS patients. The decrease in BMP-9 levels in the liver and ovaries may be involved in IR through the PI3K/AKT signaling pathway in PCOS rats."

基金机构：National Natural Science Foundation of China [82060273]; Youth Science and Technology Talent Development Project of Guizhou Education Department [237]

基金资助正文："The study was supported by the National Natural Science Foundation of China (grant no. 82060273) and Youth Science and Technology Talent Development Project of Guizhou Education Department, KY[2018] No. 237."