Relationship Between Linezolid Exposure and the Typical Clinical Laboratory Safety and Bacterial Clearance in Chinese Pediatric Patients

作者全名："Huo, Ben-Nian; Wu, Yue-E.; Shu, Ling; Zhang, Ruo-Qi; Xiao, Jian-Wen; Li, Qian-Bo; Zhao, Wei; Jia, Yun-Tao; Song, Lin"

作者地址："[Huo, Ben-Nian; Shu, Ling; Jia, Yun-Tao; Song, Lin] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Children, Dept Pharm, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Wu, Yue-E.; Zhao, Wei] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Clin Pharm,Minst Educat, Jinan, Peoples R China; [Zhang, Ruo-Qi] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China; [Xiao, Jian-Wen] Chongqing Med Univ, Childrens Hosp, Dept Hematol, Chongqing, Peoples R China; [Li, Qian-Bo] Chongqing Med Univ, Childrens Hosp, Dept Informat Ctr, Chongqing, Peoples R China; [Zhao, Wei] Qilu Hosp Shandong Univ, Shandong Univ, NMPA Key Lab Clin Res & Evaluat Innovat Drug, Jinan, Peoples R China"

通信作者："Jia, YT; Song, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Children, Dept Pharm, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000840777400001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：linezolid; exposure; safety; efficacy; paediatric

摘要："Objectives: There have been limited studies concerning the safety and efficacy of linezolid (LZD) in children. This study aimed to evaluate the association between LZD exposure and clinical safety and efficacy in Chinese pediatric patients.Methods: This retrospective cross-sectional study included patients <= 18 years of age who received >= 3 days of LZD treatment between 31 January 2015, and 31 December 2020. Demographic characteristics, medication information, laboratory test information, and bacterial culture results were collected from the Hospital Information System (HIS). Exposure was defined as AUC(24) and calculated by the non-linear mixed-effects modeling program (NONMEM), version 7.2, based on two validated population pharmacokinetic models. Binary logistic regression analyses were performed to analyze the associations between AUC(24) and laboratory adverse events, and receiver operating characteristic curves were used to calculate the cut-off values. Efficacy was evaluated by bacterial clearance.Results: A total of 413 paediatric patients were included, with an LZD median (interquartile range) dose, duration, clearance and AUC(24) of 30.0 (28.1-31.6) mg/kg/day, 8 (4-15) days,1.31 (1.29-1.32) L/h and 81.1 (60.6-108.7) mg/L center dot h, respectively. Adverse events associated with TBil, AST, ALT, PLT, hemoglobin, WBC, and neutrophil count increased during and after LZD treatment when compared with before medication (p < 0.05), and the most common adverse events were thrombocytopaenia (71/399, 17.8%) and low hemoglobin (61/401, 15.2%) during the LZD treatment. Patients with AUC(24) higher than 120.69 mg/L h might be associated with low hemoglobin 1-7 days after the end of the LZD treatment, and those with an AUC(24) higher than 92.88 mg/L center dot h might be associated with thrombocytopaenia 8-15 days after the end of the LZD treatment. A total of 136 patients underwent bacterial culture both before and after LZD treatment, and the infection was cleared in 92.6% (126/136) of the patients, of whom 69.8% (88/126) had AUC(24)/MIC values greater than 80.Conclusion: Hematological indicators should be carefully monitored during LZD treatment, especially thrombocytopaenia and low hemoglobin, and a continuous period of monitoring after LZD withdrawal is also necessary. Since the AUC(24) cut-off values for laboratory adverse events were relatively low, a trade-off is necessary between the level of drug exposure required for treatment and safety, and the exposure target (AUC(24)/MIC) in pediatric patients should be further studied, especially for patients with complications and concomitant medications."

基金机构：Chongqing Clinical pharmacy Key Specialty Construction Project; National Natural Science Foundation of China; Young Taishan Scholars Program of Shandong Province; Distinguished Young and Middle-aged Scholar of Shandong University; [82173897]

基金资助正文：Funding This research was supported by the following research grants: Chongqing Clinical pharmacy Key Specialty Construction Project; the National Natural Science Foundation of China (82173897); Young Taishan Scholars Program of Shandong Province; Distinguished Young and Middle-aged Scholar of Shandong University.