Causal analysis of serum polyunsaturated fatty acids with juvenile idiopathic arthritis and ocular comorbidity

作者全名："Shu, Qinxin; Zhao, Chenyang; Yu, Jing; Liu, Yusen; Hu, Shuqiong; Meng, Jiayu; Zhang, Jun"

作者地址："[Shu, Qinxin; Zhao, Chenyang; Liu, Yusen; Meng, Jiayu; Zhang, Jun] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Shu, Qinxin; Zhao, Chenyang; Liu, Yusen; Meng, Jiayu; Zhang, Jun] Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Shu, Qinxin; Zhao, Chenyang; Liu, Yusen; Meng, Jiayu; Zhang, Jun] Chongqing Eye Inst, Chongqing, Peoples R China; [Shu, Qinxin; Zhao, Chenyang; Liu, Yusen; Meng, Jiayu; Zhang, Jun] Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China; [Yu, Jing] Chongqing Med Univ, Affiliated Hosp 1, Dept Geriat, Chongqing, Peoples R China; [Hu, Shuqiong] Wuhan Univ, Wuhan Aier Eye Hosp, Wuhan, Hubei, Peoples R China"

通信作者："Zhang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhang, J (通讯作者)，Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China.; Zhang, J (通讯作者)，Chongqing Eye Inst, Chongqing, Peoples R China.; Zhang, J (通讯作者)，Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000841048400002

JCR分区：Q2

影响因子：4.7

年份：2022

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期号：　

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文献类型：Article; Early Access

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摘要："Background & objective To investigate the causal effects of plasma Polyunsaturated fatty acids (PUFAs) on the risk of juvenile idiopathic arthritis (JIA) and ocular comorbidity through Mendelian randomization (MR) analysis. Methods Genetic variants (formerly single nucleotide polymorphisms, SNPs) that are strongly associated with PUFAs levels (P < 5x10(-8)) were selected as instrumental variables. Summary-level MR was performed with outcome estimates for JIA (n = 31,142) and JIA associated iridocyclitis (n = 94,197). The inverse variance-weighted (IVW) method was employed as the main approach to combine the estimation for each SNP. Two set of models with summary statistics were conducted and multiple sensitivity analyses were applied for testing of pleiotropic bias. Results In model 1, genetically predicted n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) were associated with lower and higher risk of JIA associated iridocyclitis using IVW (ORLA = 0.940, 95% CI: 0.895-0.988, P = 0.015; ORAA = 1.053, 95% CI: 1.007-1.101, P = 0.024). No such association was observed between each plasma PUFAs and JIA susceptibility (P > 0.05). In further MR analysis, results from model 2 also showed a consistent trend. Besides, multiple sensitivity analyses revealed that there was no obvious evidence for unknown pleiotropy (P > 0.05). Conclusions Our MR study provides genetic evidence on the possible causality that plasma LA level might protect against JIA associated iridocyclitis, whereas AA was responsible for opposite effect."

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