The role of fibrinogen in traumatic brain injury: from molecular pathological mechanisms to clinical management

作者全名："Peng, Shixin; Lv, Ke"

作者地址："[Peng, Shixin; Lv, Ke] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Lv, K (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000841151500001

JCR分区：Q2

影响因子：2.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Traumatic brain injury; Fibrinogen; Central nervous system; Mechanisms; Management

摘要："Fibrinogen is the substrate of plasma coagulation. It plays an important role in the formation of reticular network, which is crucial to the strength and stability of blood clots. In addition to directly participating in coagulation, fibrinogen also participates in the destruction of blood-brain barrier and neuroinflammation. This article reviews the pathophysiological changes of fibrinogen after traumatic brain injury. Considerable efforts have been made to understand the mechanisms by which fibrinogen damages the central nervous system. Combined with the latest research hotspots, potentially promising treatment strategies at the molecular level were discussed. We believe that understanding the role of fibrinogen-mediated damage in nerve and blood-brain barrier function will enable timely intervention in patients with nerve damage, and guide the development of novel targeted therapeutics."

基金机构：National Natural Science Foundation of China

基金资助正文：The present study was funded by National Natural Science Foundation of China.