Metabolic Basis of Cognitive Improvement Associated With Active B Vitamin Supplementation in Cognitively Impaired Elderly Subjects - A Metabolomics Study

作者全名："Zhou, Haiming; Wu, Yuanyuan; Jiang, Binhua; Li, Bowen; Li, Martin; Tian, He; Shui, Guanghou; Lam, Sin Man; Kwok, Timothy"

作者地址："[Zhou, Haiming; Jiang, Binhua; Li, Bowen; Lam, Sin Man] LipidALL Technol Co Ltd, Changzhou, Peoples R China; [Wu, Yuanyuan] Chongqing Med Univ, Hlth Management Ctr, Affiliated Hosp 2, Chongqing, Peoples R China; [Wu, Yuanyuan; Li, Martin; Kwok, Timothy] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China; [Tian, He; Shui, Guanghou; Lam, Sin Man] Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China"

通信作者："Lam, SM (通讯作者)，LipidALL Technol Co Ltd, Changzhou, Peoples R China.; Kwok, T (通讯作者)，Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.; Lam, SM (通讯作者)，Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000841978200001

JCR分区：Q1

影响因子：3.9

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：metabolomics; B vitamins; aspirin; cognitive impairment; dementia

摘要："Intervention studies with active B vitamin supplementation in cognitively impaired individuals have yielded varying results in randomized controlled trials. In addition, a negative interaction of active B vitamin supplementation with aspirin usage on cognitive outcome was noted, but the molecular basis of the interaction has largely remained unknown. To investigate the metabolic basis of cognitive improvement brought about by active B vitamin supplementation, we conducted an extensive metabolomics analysis covering 302 identified metabolites on the baseline and 24-month serum samples from a cohort of 137 subjects randomly assigned to active supplementation or placebo. Pathway analysis uncovered enhanced gluconeogenesis and War-burg effects underlying cognitive improvement in non-aspirin users supplemented with active B vitamins. In addition, metabolomics revealed that aspirin usage may interact with B vitamin supplementation by altering gut microbial metabolism, particularly in terms of propionate production. Lastly, our omics data suggest that varying capacities to assimilate B vitamins at baseline, possibly mediated by differences in gut microbial composition, may underlie variations in inter-individual responses to active B vitamin supplementation."

基金机构：Hong Kong Research Grant Council [466612]; National Key R&D Program of China [2018YFA0800901]

基金资助正文：This study was supported by the General Research Grant from the Hong Kong Research Grant Council (Ref No. 466612) and the National Key R&D Program of China (2018YFA0800901).