Polycyclic aromatic hydrocarbons are associated with later puberty in girls: A longitudinal study

作者全名："Fang, Bo; Bravo, Mercedes A.; Wang, Hong; Sheng, Lulu; Wu, Wenyi; Zhou, Yuanke; Xi, Xuan; ostbye, Truls; Liu, Qin"

作者地址："[Fang, Bo; Wang, Hong; Sheng, Lulu; Wu, Wenyi; Zhou, Yuanke; Xi, Xuan; Liu, Qin] Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing, Peoples R China; [Bravo, Mercedes A.] Duke Univ, Duke Global Hlth Inst, Durham, NC USA; [ostbye, Truls] Duke Univ, Duke Global Hlth Inst, Dept Family Med & Community Hlth, Durham, NC USA; [Liu, Qin] Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Liu, Q (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：SCIENCE OF THE TOTAL ENVIRONMENT

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000841995700014

JCR分区：Q1

影响因子：9.8

年份：2022

卷号：846

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Polycyclic aromatic hydrocarbons (PAHs); Puberty; Urinary PAHs metabolites; Tanner stages; Menarche

摘要："The objective of this study is to explore associations between PAH exposures and puberty timing in girls. Beginning in May 2014, 734 girls age 7.2-11.8 years in Chongqing, China, were enrolled in a prospective cohort study. They were followed up every 6 months from enrollment through June 2021, at which point participants were ages 13.6-18.3 years. Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline. At each follow up visit, the Tanner's Sexual Maturity Rating scale was administered. Cox proportional hazards models were used to estimate associations between four urinary PAH metabolite concentrations and four markers of puberty: menarche, breast development, pubic hair development, and axillary hair development. Geometric mean concentrations of 1-OHPyr, 2-OHNap, 2-OHFlu and 9-OHPhe in urine were 0.47 mu g/L, 3.31 mu g/L, 1.49 mu g/L, 3.75 mu g/L, respectively. There were statistically significant associations between several urinary PAH metabolite concentrations and puberty out-comes. PAH metabolite concentrations were grouped as Low (<25th percentile, referent group), Moderate (25th-75th percentile) or High (>75th). Girls with moderate levels of 1-OHPyr were at higher risk of delayed pubic hair development (hazard ratio [HR]: 0.82, 95 % confidence interval [CI]: 0.68-0.99). Delayed breast development (HR: 0.77, 95 % CI: 0.60-0.99) and pubic hair development (HR:0.76, 95 % CI: 0.60-0.95) were associated with high 2-OHNap. High c 2-OHFlu was associated with delayed pubic hair development (HR: 0.77, 95 % CI: 0.61-0.96). Delayed breast (HR: 0.79, 95 % CI: 0.64-0.97), pubic hair (HR:0.79, 95 % CI: 0.65-0.96) and axillary hair development (HR: 0.80, 95 % CI: 0.65-0.99) was associated with moderate 9-OHPhe. In conclusion, PAH exposure may delay puberty onset in girls."

基金机构："National Science Fund Project [81973067]; National Youth Science Fund Project [81502825]; Venture & Innovation Support Program for Chongqing Over- seas Returnees, China [cx2018105]; Basic and Frontier Research Project of Chongqing Science and Technology Commission [cstc2013jcyjA10001]; Chongqing Medical University Future Medical Innovation Team Support Program [W0054]"

基金资助正文："This work was supported by National Science Fund Project (Granted NO: 81973067) , National Youth Science Fund Project (Granted NO: 81502825) , Venture & Innovation Support Program for Chongqing Over- seas Returnees, China (grant numbers cx2018105) , Basic and Frontier Research Project of Chongqing Science and Technology Commission (Grant No. cstc2013jcyjA10001) , and Chongqing Medical University Future Medical Innovation Team Support Program (W0054) ."