Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research

作者全名："Lin, Lirong; Tian, En; Ren, Jiangwen; Wu, Zhifeng; Deng, Junhui; Yang, Jurong"

作者地址："[Lin, Lirong; Tian, En; Wu, Zhifeng; Yang, Jurong] Chongqing Med Univ, Gen Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China; [Ren, Jiangwen] Jiulongpo Dist Peoples Hosp Chongqing, Dept Nephrol Rheumatism & Immunol, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Gen Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000843187200001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：traditional Chinese medicine; minimal change disease; idiopathic membranous nephropathy; focal segmental glomerulosclerosis; podocyte

摘要："Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as ""podocyte disease."" There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations. Primary podocytosis mostly manifests as nephrotic syndrome. At present, first-line treatment is based on glucocorticoid administration combined with immunosuppressive therapy, but some patients still progress to end-stage renal disease. In Asia, especially in China, traditional Chinese medicine (TCM) still plays an important role in the treatment of kidney diseases. This study summarizes the potential mechanism of TCM and its active components in protecting podocytes, such as repairing podocyte injury, inhibiting podocyte proliferation, reducing podocyte apoptosis and excretion, maintaining podocyte skeleton structure, and upregulating podocyte-related protein expression. At the same time, the clinical efficacy of TCM in the treatment of primary podocytosis (including idiopathic membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis) is summarized to support the development of new treatment strategies for primary podocytosis."

基金机构：National Natural Science Foundation of China [81770682]; Basic and Frontier Research Program of Chongqing [cstc2017jcyjBX0014]; Chongqing Talent Program Project [cstc2021ycjh-bgzxm0090]; Special Project for Technological Innovation and Application Development of Chongqing [cstc2019jscx-msxmX0166]

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81770682), the Basic and Frontier Research Program of Chongqing (cstc2017jcyjBX0014), the Chongqing Talent Program Project (cstc2021ycjh-bgzxm0090),and the Special Project for Technological Innovation and Application Development of Chongqing (cstc2019jscx-msxmX0166)."