Polyglycerol fatty acid esters as alternatives to PEGylated lipids for liposome coating

作者全名："Chen, Huali; Zhang, Qianyu"

作者地址："[Chen, Huali; Zhang, Qianyu] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Zhang, QY (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：NANOMEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000843500100001

JCR分区：Q2

影响因子：5.5

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：anti-PEG IgM; liposomes; PEGylation; pharmacokinetics; polyglycerol fatty acid esters

摘要："Background: Polyglycerol (PG) is a type of biocompatible hydrophilic polyether polyol, and it is considered as a potential alternative to polyethylene glycol (PEG) in modifying nanomedicines. Materials & methods: Polyglycerol fatty acid esters (PGFEs) were modified onto liposomes and their serum stability, pharmacokinetics, in vivo distribution and the capacity to induce anti-PEG IgM were compared with PEGylated liposomes (PEG-Lips). Results: Polyglycerol 10-monostearate (PG-10-MS) displayed considerable serum stability and compatibility with mice red blood cells, and it significantly prolonged the blood circulation of liposomes in the pharmacokinetics study compared with the unmodified liposomes, with a similar biodistribution pattern to that of the PEG-Lips. Moreover, PGFE-modified liposomes were less likely to induce the production of anti-PEG IgM. Conclusion: PGFEs could be considered as good candidates to replace PEG lipids for the preparation of liposomes."

基金机构：National Natural Science Foundation for Young Scientists of China [81903549]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000407]

基金资助正文：This work was supported by the National Natural Science Foundation for Young Scientists of China (grant no. 81903549) and the Science and Technology Research Program of Chongqing Municipal Education Commission (grant no. KJQN202000407). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.