Computational identification of immune-related lncRNA signature for predicting the prognosis and immune landscape of human glioblastoma multiforme

作者全名："Shi, Dongjie; Zhong, Wenjie; Liu, Dan; Sun, Xiaochuan; Hao, Shilei; Yang, Yaying; Ao, Lei; Zhou, Junjie; Xia, Yongzhi; Zhou, Yudong; Yu, Hua; Xia, Haijian"

作者地址："[Shi, Dongjie; Zhong, Wenjie; Sun, Xiaochuan; Ao, Lei; Xia, Yongzhi; Yu, Hua; Xia, Haijian] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China; [Liu, Dan] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Pharm, Chongqing, Peoples R China; [Hao, Shilei] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China; [Yang, Yaying; Zhou, Junjie] Chongqing Med Univ, Mol Med & Tumor Ctr, Dept Pathol, Chongqing, Peoples R China; [Zhou, Yudong] Chongqing Med Univ, Childrens Hosp, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Xia, HJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000844894300001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：glioblastoma multiforme; immune-related long noncoding RNAs; prognosis; immune checkpoint inhibitors; effectiveness

摘要："Emerging evidence shows immune-related long noncoding RNAs (ir-lncRNAs) perform critical roles in tumor progression and prognosis assessment. However, the identification of ir-lncRNAs and their clinical significance in human glioblastoma multiforme (GBM) remain largely unexplored. Here, a designed computational frame based on immune score was used to identify differentially expressed ir-lncRNAs (DEir-lncRNAs) from The Cancer Genome Atlas (TCGA) GBM program. The immune-related lncRNA signature (IRLncSig) composed of prognosis-related DEir-lncRNAs selected by Cox regression analysis and its clinical predictive values were verified, which was further validated by another dataset from the Gene Expression Omnibus database (GEO). Subsequently, the association between IRLncSig and immune cell infiltration, immune checkpoint inhibitor (ICI) biomarkers, O6-methylguanine-DNA methyltransferase (MGMT) gene expression, and biological function were also analyzed. After calculation, five prognosis-related ir-lncRNAs were included in the establishment of IRLncSig. The risk assessment based on IRLncSig indicated that the high-IRLncSig-score group was significantly associated with poor prognosis (p < 0.001), significant aggregation of macrophages (p < 0.05), higher ICI biomarker expression, and MGMT gene expression (p < 0.05). Signature-related lncRNAs may be involved in immune activities in the tumorigenesis and progression of GBM. In summary, the novel IRLncSig shows a promising clinical value in predicting the prognosis and immune landscape of GBM."

基金机构：Chongqing Natural Science Foundation; [2022NSCQ-MSX0963]

基金资助正文：Funding The research was funded by Chongqing Natural Science Foundation (Application number: 2022NSCQ-MSX0963).