Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma

作者全名："Li, Lanqing; Wang, Xiaoqiang; Xu, Haiying; Liu, Xianqiong; Xu, Kang"

作者地址："[Li, Lanqing; Wang, Xiaoqiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Chongqing, Peoples R China; [Li, Lanqing; Xu, Haiying; Liu, Xianqiong; Xu, Kang] Hubei Univ Chinese Med, Coll Pharm, Hubei Engn Technol Res Ctr Chinese Mat Med Proc, Wuhan, Peoples R China"

通信作者："Wang, XQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Chongqing, Peoples R China.; Xu, K (通讯作者)，Hubei Univ Chinese Med, Coll Pharm, Hubei Engn Technol Res Ctr Chinese Mat Med Proc, Wuhan, Peoples R China."

来源：FRONTIERS IN MOLECULAR BIOSCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000848348200001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：ferroptosis; hepatocellular carcinoma; cell death; molecular signaling; targeted therapy

摘要："Ferroptosis is a novel process of regulated cell death discovered in recent years, mainly caused by intracellular lipid peroxidation. It is morphologically manifested as shrinking of mitochondria, swelling of cytoplasm and organelles, rupture of plasma membrane, and formation of double-membrane vesicles. Work done in the past 5 years indicates that induction of ferroptosis is a promising strategy in the treatment of hepatocellular carcinoma (HCC). System xc(-)/GSH/GPX4, iron metabolism, p53 and lipid peroxidation pathways are the main focus areas in ferroptosis research. In this paper, we analyze the ferroptosis-inducing drugs and experimental agents that have been used in the last 5 years in the treatment of HCC. We summarize four different key molecular mechanisms that induce ferroptosis, i.e., system xc(-)/GSH/GPX4, iron metabolism, p53 and lipid peroxidation. Finally, we outline the prognostic analysis associated with ferroptosis in HCC. The findings summarized suggest that ferroptosis induction can serve as a promising new therapeutic approach for HCC and can provide a basis for clinical diagnosis and prevention of this disease."

基金机构："Hubei University of Chinese Medicine ""Young Crops Program"" Project [2021ZZX003]; Natural Science Foundation of Hubei Province, China [2021CFB227]; Hubei Provincial Central Government Guided Local Science and Technology Development Special Project ""Traditional Chinese Herbal Medicine Properties and Quality Evaluation Platform"" [2020ZYYD030]; Chongqing Natural Science Foundation [cstc2019jcyj-msxmX0862]"

基金资助正文："This work was supported by Hubei University of Chinese Medicine ""Young Crops Program"" Project (2021ZZX003). Natural Science Foundation of Hubei Province, China (Grant No. 2021CFB227), Hubei Provincial Central Government Guided Local Science and Technology Development Special Project ""Traditional Chinese Herbal Medicine Properties and Quality Evaluation Platform"" (2020ZYYD030). This work was supported by the Chongqing Natural Science Foundation (Grant number: cstc2019jcyj-msxmX0862)."