Role of leptin/ILC2 axis in allergic rhinitis in obese children

作者全名："Wang, Xiaoqiang; Shen, Yang; Ke, Xia; Kang, Houyong; Hong, Suling"

作者地址："[Wang, Xiaoqiang; Shen, Yang; Ke, Xia; Kang, Houyong; Hong, Suling] Chongqing Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Wang, XQ (通讯作者)，1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000849774200007

JCR分区：Q2

影响因子：1.5

年份：2022

卷号：157

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Allergic rhinitis; Leptin; Obesity; Type 2 innate lymphoid cells

摘要："Objectives: Since the leptin participates in the upregulation of type 2 innate lymphoid cells (ILC2s). We investigated the role of the leptin/ILC2 axis in AR pathogenesis in Chinese paediatric patients with obesity. Methods: Seventy AR paediatric patients with or without obesity and 30 healthy obese subjects were enrolled. The levels of leptin, its receptor and ILC2 milieu were measured, and correlations between them and clinical symptom severity and between ILC2 milieu and leptin levels were assessed. Changes of ILC2 milieu in AR patients after leptin stimulation were also detected. Results: Levels of leptin, its receptor and ILC2 milieu levels were significantly higher in the disease than in the controls, and highest in the obese-AR group. The leptin/ILC2 axis and severity of clinical symptoms in obese patients with AR were significantly correlated, similarly to what was observed between leptin/leptin receptors and ILC2 milieu. Recombinant leptin could significantly increased the levels of ILC2 milieu in the obese-AR group. Conclusions: These findings suggest the unique function of the leptin/ILC2 axis in obese paediatric AR patients. The mechanism by which obesity promotes AR in paediatric patients may be related to the leptin/ILC2 axis."

基金机构：Chongqing Natural Science Foundation [cstc2019jcyj-msxmX0862]

基金资助正文："We would like to thank Dr. Cheng Zhang (Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Chongqing Medical University) for his generosity and availability in providing part of the experimental specimen required for the present study. This work was supported by the Chongqing Natural Science Foundation [grant number: cstc2019jcyj-msxmX0862]."