"A multicenter, randomized, open, controlled trial to evaluate the efficacy of Honglilai Vaginal Cream and Premarin Vaginal Cream for Genitourinary Syndrome of Menopause in different subgroups of Chinese postmenopausal women"

作者全名："Yang, Mukun; Lin, Shouqing; Zheng, Shurong; Sun, Aijun; Bian, Meilu; Li, Shilan; Liu, Jianli; Hu, Lina; Hui, Ning; Zhong, Jing; Hou, Hongchun; Yue, Tianfu; Gao, Xiaoli; Bai, Wenpei"

作者地址："[Yang, Mukun; Bai, Wenpei] Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China; [Lin, Shouqing; Sun, Aijun] Peking Union Med Coll Hosp, Beijing, Peoples R China; [Zheng, Shurong] Peking Univ, Hosp 1, Beijing, Peoples R China; [Bian, Meilu] China Japan Friendship Hosp, Beijing, Peoples R China; [Li, Shilan] Peking Univ, Hosp 3, Beijing, Peoples R China; [Liu, Jianli] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China; [Hu, Lina] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China; [Hui, Ning] Changhai Hosp Shanghai, Shanghai, Peoples R China; [Zhong, Jing] Chengdu Matern & Child Care Hosp, Chengdu, Peoples R China; [Hou, Hongchun] Jinan Matern & Child Care Hosp, Jinan, Peoples R China; [Yue, Tianfu] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China; [Gao, Xiaoli] Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Xinjiang, Peoples R China"

通信作者："Gao, XL (通讯作者)，Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Xinjiang, Peoples R China.; Bai, WP (通讯作者)，Capital Med Univ, Beijing Shijitan Hosp, Dept Obstet & Gynecol, Beijing 100038, Peoples R China."

来源：GYNECOLOGICAL ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000850865600001

JCR分区：Q3

影响因子：2

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Genitourinary Syndrome of Menopause; Vaginal Maturation Index; Honglilai Vaginal Cream; Premarin Vaginal Cream; age

摘要："Aim In a randomized, multicenter, open, controlled trial, we compared the effects of Honglilai Vaginal Cream and Premarin Vaginal Cream in different age subgroups and menopausal year subgroups (trial registration numbers: 02003L00493). Methods Postmenopausal women with Genitourinary Syndrome of Menopause (GSM) were divided into Honglilai group (n = 319) and Premarin group (n = 116), while subgroups were divided according to their different characteristics of age and menopausal years. Honglilai Vaginal Cream (0.625 mg/g) or Premarin Vaginal Cream (0.625 mg/g) once daily for 3 weeks. Results In the subgroup of participates >60 years, there were no significant differences of Vaginal Cell Maturation Index (VMI) between the two groups after treatment (p = .171). In the subgroup of 50-59 years, the VMI of Honglilai group was significantly lower than Premarin group (Honglilai group: 74.37 +/- 22.76; Premarin group: 80.06 +/- 16.15; p = .02). There were no significant differences of Vaginal symptom scores between Honglilai group and Premarin group in every sub-group (p > .05). Conclusions Honglilai Vaginal Cream had comparable efficacy with Premarin Vaginal Cream in Chinese women older than 60 years."

基金机构：Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support [ZYLX202112]; Major Science and Technology Projects of the Xinjiang Uygur Autonomous Region [2017A01002-4]

基金资助正文："This research was supported by the Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (Code: ZYLX202112), the Major Science and Technology Projects of the Xinjiang Uygur Autonomous Region (Code: 2017A01002-4)."