Transcription factor Foxp1 stimulates angiogenesis in adult rats after myocardial infarction

作者全名："Wang, Dinghui; Liu, Bin; Xiong, Tianhua; Yu, Wenlong; Yang, Huiping; Wang, Jing; Jing, Xiaodong; She, Qiang"

作者地址："[Wang, Dinghui; Liu, Bin; Xiong, Tianhua; Yu, Wenlong; Yang, Huiping; Wang, Jing; Jing, Xiaodong; She, Qiang] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China"

通信作者："She, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China."

来源：CELL DEATH DISCOVERY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000852376700001

JCR分区：Q2

影响因子：7

年份：2022

卷号：8

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Forkhead box protein P1 (FoxP1) is essential for cardiac development and the regulation of neovascularization, but its potential for cardiac angiogenesis has not been explored. This study aims to investigate the angiogenic role of FoxP1 in a rat model of myocardial infarction (MI). Adult male rats were subjected to MI, and Foxp1 was knocked down with lentivirus FoxP1 siRNA. Endothelial cell proliferation, angiogenesis, and cardiac function were also assessed. Cell scratch assay and tubule formation analysis were used to detect the migration ability and tube formation ability of human umbilical vein endothelial cells (HUVECs). Compared with that in the sham group, results showed that the expression of FoxP1 was significantly increased in the MI group. Foxp1 knockdown decreases FoxP1 expression, reduces angiogenesis, and increases collagen deposition. When Foxp1 was knocked down in HUVECs using FoxP1 siRNA lentivirus, cell proliferation, migration, and tube formation abilities decreased significantly. Our study showed that FoxP1 elicits pleiotropic beneficial actions on angiogenesis in the post-MI heart by promoting the proliferation of endothelial cells. FoxP1 should be considered a candidate for therapeutic cardiac angiogenesis."

基金机构：National Natural Science Foundation of China [81770251]; National Natural Science Foundation of China Youth Science Fund Project [81800254]; Social Undertakings and People's Livelihood Protection Technology Innovation of Chongqing Science Commission [cstc2017shmsA130086]; Chongqing city Yuzhong District Science and Technology Basic and Advanced Research Projects [20170107]

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (81770251), National Natural Science Foundation of China Youth Science Fund Project (81800254). Social Undertakings and People's Livelihood Protection Technology Innovation of Chongqing Science Commission (cstc2017shmsA130086), and Chongqing city Yuzhong District Science and Technology Basic and Advanced Research Projects (20170107)."