Total cholesterol and high density lipoprotein cholesterol ratio is associated with metabolic syndrome in a very elderly Chinese population

作者全名："Huang, Gang; Xu, Junbo; Zhang, Zhen; Cai, Lin; Liu, Hanxiong; Yu, Xiuqiong"

作者地址："[Huang, Gang; Xu, Junbo; Zhang, Zhen; Cai, Lin; Liu, Hanxiong] Third Peoples Hosp Chengdu, Dept Cardiol, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China; [Huang, Gang; Xu, Junbo; Zhang, Zhen; Cai, Lin; Liu, Hanxiong; Yu, Xiuqiong] Cardiovasc Dis Res Inst Chengdu, Chengdu, Sichuan, Peoples R China; [Huang, Gang; Xu, Junbo; Zhang, Zhen; Cai, Lin; Liu, Hanxiong; Yu, Xiuqiong] Southwest Jiaotong Univ, Affiliated Hosp, Chengdu, Sichuan, Peoples R China; [Huang, Gang; Xu, Junbo; Zhang, Zhen; Cai, Lin; Liu, Hanxiong; Yu, Xiuqiong] Chongqing Med Univ, Affiliated Chengdu Clin Coll 2, Chengdu, Sichuan, Peoples R China"

通信作者："Huang, G; Xu, JB (通讯作者)，Third Peoples Hosp Chengdu, Dept Cardiol, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China.; Huang, G; Xu, JB (通讯作者)，Cardiovasc Dis Res Inst Chengdu, Chengdu, Sichuan, Peoples R China.; Huang, G; Xu, JB (通讯作者)，Southwest Jiaotong Univ, Affiliated Hosp, Chengdu, Sichuan, Peoples R China.; Huang, G; Xu, JB (通讯作者)，Chongqing Med Univ, Affiliated Chengdu Clin Coll 2, Chengdu, Sichuan, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000852396300034

JCR分区：Q1

影响因子：4.6

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Metabolic syndrome (MetS) is currently a major public health challenge in young, middle aged and elderly population worldwide, but it is still not clear in very elderly population. This study was to investigate the potential association between total cholesterol and high density lipoprotein cholesterol ratio (THR) and MetS in a very elderly population in Chengdu. Totally, 1056 very elderly (aged >= 80 years) in Chengdu community were enrolled in this study. Geographic characteristics of participants were collected and laboratory measurement was performed. Metabolic syndrome (MetS) was defined according to the Chinese and the international diabetes federation (IDF) criteria, respectively. Logistic analysis was used to investigate the potential association between the THR and MetS. Receiver operating characteristic curve (ROC) analysis was used to evaluate the efficiency of THR in MetS predicting. Finally, 1038 participants were included in statistical analysis. The mean age was 83.6 +/- 3.4 years and 52.6% participants were men and 21.6% suffered from MetS. Participants with MetS had relatively higher waist circumference, body weight, blood pressure, fast plasma glucose level, non-high density lipoprotein cholesterol level and THR. The logistic analysis revealed that the THR was associated with MetS according to both the Chinese (odds ratio (OR): 3.053, 95% confidence interval (CI) 2.464-3.782, P < 0.001) and the IDF criteria (OR: 2.458, 95% CI 2.016-2.995, P < 0.001). ROC analysis found that the area under curve of the THR was 0.800 (95% CI 0.749-0.852, P < 0.001) and 0.727 (95% CI 0.669-0.786, P < 0.001) for predicting MetS according to the Chinese and the IDF criteria, respectively. The THR is associated with MetS in this community very elderly population in Chengdu."

基金机构："Science and Technology Bureau of Chengdu [2019-YF05-00523-SN, 11PPYB034SF]; Department of Human Resources and Social Security of Sichuan Province [2021-11]; Chengdu Municipal Health commission [2021200, 2022392]"

基金资助正文："This study was supported by the Science and Technology Bureau of Chengdu (Contracts No.: 2019-YF05-00523-SN, 11PPYB034SF), Department of Human Resources and Social Security of Sichuan Province (Contracts No.: 2021-11) and Chengdu Municipal Health commission (Contracts No.: 2021200, 2022392)."