Effect of hypoalbuminemia on short-term outcomes after colorectal cancer surgery: A propensity score matching analysis

作者全名："Kang, Bing; Zhao, Zhi-Qiang; Liu, Xiao-Yu; Cheng, Yu-Xi; Tao, Wei; Wei, Zheng-Qiang; Peng, Dong"

作者地址："[Kang, Bing; Liu, Xiao-Yu; Cheng, Yu-Xi; Tao, Wei; Wei, Zheng-Qiang; Peng, Dong] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Kang, Bing] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Zhi-Qiang] Chongqing Med Univ, Dept Gen Surg, Affiliated Hosp 1, Qijiang Hosp, Chongqing, Peoples R China"

通信作者："Peng, D (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000852659900001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：colorectal cancer; hypoalbuminemia; outcomes; complications; surgery

摘要："PurposeThe purpose of our study was to investigate the effect of pre-operative hypoalbuminemia on the short-term outcomes after primary colorectal cancer (CRC) surgery. Materials and methodsThe retrospective study enrolled CRC patients who underwent primary surgery from January 2011 to December 2021 in a single teaching hospital. The short-term outcomes were compared between the hypoalbuminemia group and the normal group using propensity score matching (PSM). Univariate and multivariate logistic regression analyses were used for analyzing independent predictors of overall complications and major complications. ResultsA total of 7,072 patients from a single center were enrolled in this study. There were 1,078 (15.2%) patients in the pre-operative hypoalbuminemia group and 5,994 (84.8%) patients in the normal pre-operative albumin group. After 1:1 PSM, there were 1,028 patients in the hypoalbuminemia group and 1,028 patients in the normal group. No significant differences were found in baseline information between the two groups after PSM. In terms of short-term outcomes, the hypoalbuminemia group had a longer operation time (p = 0.003), greater volume of blood loss (p = 0.036), longer hospital stays (p < 0.01), higher proportion of overall complications (p = 0.003), major complications (p = 0.016), higher incidence of pneumonia and abdominal infection (p = 0.001) than the normal group after PSM. Furthermore, hypoalbuminemia was an independent predictor for overall complications (p = 0.008) and major complications (p = 0.016). ConclusionPre-operative hypoalbuminemia increased overall complications and major complications after primary CRC surgery. Furthermore, hypoalbuminemia was an independent predictor for overall complications and major complications."

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