A semiquantitative study of the optimal whole-body imaging time after I-131 therapy for differentiated thyroid cancer

作者全名："Liu, Shuang; Zuo, Rui; Yang, Tianyu; Pang, Hua; Wang, Zhengjie"

作者地址："[Liu, Shuang; Zuo, Rui; Yang, Tianyu; Pang, Hua; Wang, Zhengjie] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China"

通信作者："Pang, H; Wang, ZJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000855034900001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：differentiated thyroid carcinoma; post-therapy I-131 whole-body scan; semiquantitative study; visual analysis; optimal imaging time

摘要："ObjectiveWe compared the efficacy of post-therapy whole-body scintigraphy (Tx-WBS) in terms of detecting lesions in patients with differentiated thyroid cancer (DTC) on days 3, 7, and 10 after I-131 treatment, and we determined the optimal imaging time. MethodsClinical data from 161 DTC patients treated with I-131 were collected. All patients underwent day 3 imaging, but only 98 patients underwent day 3 and day 7 imaging, and 63 patients underwent day 3 and day 10 imaging at the same time. And the thyroid bed uptake was visually graded. The radioactivity ratios of the thyroid bed, neck lymph nodes, lungs, and liver (to the background) were calculated to allow a semiquantitative analysis. ResultsVisual analysis showed that delayed imaging revealed more lymph node and lung radioactivity, early imaging showed more residual thyroid tissue, and significant differences in uptake were apparent at days 3, 7, and 10 (P < 0.001). Semiquantitative analysis revealed significant differences in the target-to-background ratios of the residual thyroid bed, lungs, and liver at days 3, 7, and 10. On these days, the imaging sensitivities in terms of detecting metastatic lymph nodes were 29.58%, 39.02%, and 19.35%, and the specificities were 75.56%, 75.86%, and 75% (P = 0.465, 0.154, and 0.763, respectively). In terms of lung metastasis detection, the sensitivities were 29.58%, 38.46%, and 13.33% respectively, and the specificities were 98.33%, 100%, and 95.83% (P < 0.001, < 0.001, and P=0.238). ConclusionMore residual thyroid tissue can be detected by imaging on day 3; imaging on day 7 more effectively detects lung metastases than does imaging on day 3 or 10."

基金机构："Chongqing medical scientific research project [2021MSXM042]; General program of Chongqing Nature Science Foundation [cstc2020jcyj-maxmX0713, 0301020499QC-W0117]"

基金资助正文："This work is supported by Chongqing medical scientific research project (2021MSXM042).General program of Chongqing Nature Science Foundation (cstc2020jcyj-maxmX0713, 0301020499QC-W0117)."